L'Abbate N, Virgintino D, Ribatti D, Roncali L, Miccoli M G, Ambrosi L
Istituto di Medicina del Lavoro, Università degli Studi di Bari.
G Ital Med Lav. 1986 May-Jul;8(3-4):123-6.
Experimental studies have been carried out to evaluate the effects of carbaryl (l.-naphthyl-methyl-carbamate)- an anticholinesterase pesticide - on the morphogenesis and development of the chick embryo. A solution containing 0.5 mg of carbaryl has been injected in the allantoic sac of the embryos treated (n = 130), at the 5th or 6th incubation day. In comparison with a control group (= 70), some morphological alterations have been found in the embryos treated, at the expense of the skeleton apparatus, particularly in the most distal portions of the lower limbs, as tibial and metatarsal angulations, with their curtailment. Such effects might be related to an interference in the synthesis of NAD (nicotinamide-adenine-dinucleotide), as reported for other organophosphoric pesticides.
已开展实验研究，以评估抗胆碱酯酶农药西维因（1-萘基-甲基-氨基甲酸酯）对鸡胚形态发生和发育的影响。在孵化第5天或第6天，将含有0.5毫克西维因的溶液注射到130只受试胚胎的尿囊囊中。与70只对照组胚胎相比，受试胚胎出现了一些形态学改变，主要累及骨骼系统，尤其是下肢最远端部分，如胫骨和跖骨角度异常及其缩短。正如其他有机磷农药的情况一样，这些影响可能与对烟酰胺腺嘌呤二核苷酸（NAD）合成的干扰有关。
