T 细胞衍生的细胞因子增强了人类中性粒细胞的抗原呈递能力。
T-cell-derived cytokines enhance the antigen-presenting capacity of human neutrophils.
机构信息
Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
Institute of Immunology, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
出版信息
Eur J Immunol. 2019 Sep;49(9):1441-1443. doi: 10.1002/eji.201848057. Epub 2019 Aug 6.
Abstract
Activated allergen-specific Th2 and Th1 cells release cytokines that transform neutrophils into functional APCs characterized by the expression of HLA-DR and CD58 as well as enhanced survival and antigen uptake, irrespectively of the presence of IL-10, which reduces allergen uptake by neutrophils.
摘要
被激活的变应原特异性 Th2 和 Th1 细胞释放细胞因子，将中性粒细胞转化为功能性 APCs，其特征是表达 HLA-DR 和 CD58 以及增强的存活和抗原摄取，而与 IL-10 的存在无关，IL-10 会降低中性粒细胞对变应原的摄取。
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