Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Nano Drug Delivery research center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Curr Pharm Biotechnol. 2019;20(13):1122-1133. doi: 10.2174/1389201020666190722161004.
Periodontal disease is the most common oral condition that affects the tissue surrounding the teeth. The oral cavity is colonized by an impressive array of micro-organisms, many of which can colonize the implants such as Guided Tissue Regeneration (GTR) often utilized in recovering procedures that result in inflammation interfering with the bone regeneration.
In the current study, a nano-hybrid GTR membrane is developed as a heliacal structure scaffold with localized drug delivery function (Ibuprofen) as an anti-inflammatory agent. Polycaprolactone (PCL) and a blend of Polyvinyl alcohol (PVA)/collagen (Col) (50/50) were electrospun by electrospinning. Ibuprofen (Ibu) was loaded once in the PCL context and once in the hydrophilic portion (PVA/Col).
The in vitro release behavior was investigated in each case. Chemical and physical properties were studied for each item. Morphology investigation indicated a heliacal structure with the total average diameter of 1266 nm consististing of porous pores with the average diameter of 256nm.
The membranes indicated proper mechanical properties and appropriate biodegradation rate as a potential GTR membrane. The controlled and sustained release of Ibu was obtained from both PCL and PVA/COL loaded membranes. Kinetic model study indicated the following zero-order and Higuchi models for the optimum case of PCL loaded and PVA/Col Ibu loaded scaffolds respectively.
牙周病是最常见的口腔疾病，影响牙齿周围的组织。口腔中定植着大量的微生物，其中许多微生物可以定植在引导组织再生（GTR）等植入物上，这些植入物常用于恢复过程中，但会导致炎症干扰骨再生。
在目前的研究中，开发了一种纳米杂化 GTR 膜作为一种螺旋结构支架，具有局部药物输送功能（布洛芬）作为抗炎剂。聚己内酯（PCL）和聚乙烯醇（PVA）/胶原蛋白（Col）（50/50）的混合物通过静电纺丝进行静电纺丝。布洛芬（Ibu）在 PCL 环境中加载一次，在亲水性部分（PVA/Col）中加载一次。
在每种情况下都研究了体外释放行为。对每个项目进行了化学和物理性质的研究。形态学研究表明，具有总平均直径为 1266nm 的螺旋结构，由平均直径为 256nm 的多孔组成。
这些膜具有适当的机械性能和合适的生物降解率，是一种有潜力的 GTR 膜。从负载 PCL 和 PVA/COL 的膜中均获得了布洛芬的控释和持续释放。动力学模型研究表明，对于 PCL 负载和 PVA/Col 负载支架的最佳情况，分别遵循零级和 Higuchi 模型。
