College of Veterinary Medicine, Northwest A & F University, Yangling, China.
Animal Health and Epidemiology Center, Qingdao, China.
Front Immunol. 2019 Jul 4;10:1551. doi: 10.3389/fimmu.2019.01551. eCollection 2019.
The human body is inhabited by a diverse microbial community that is collectively coined as commensal microbiota. Recent research has greatly advanced our understanding of how the commensal microbiota affects host health. Among the various kinds of pathogenic infections of the host, viral infections constitute one of the most serious public health problems worldwide. During the infection process, viruses may have substantial and intimate interactions with the commensal microbiota. A plethora of evidence suggests that the commensal microbiota regulates and is in turn regulated by invading viruses through diverse mechanisms, thereby having stimulatory or suppressive roles in viral infections. Furthermore, the integrity of the commensal microbiota can be disturbed by invading viruses, causing dysbiosis in the host and further influencing virus infectivity. In the present article, we discuss current insights into the regulation of viral infection by the commensal microbiota. We also draw attention to the disruption of microbiota homeostasis by several viruses.
人体中栖息着多种多样的微生物群落，这些微生物被统称为共生微生物菌群。最近的研究极大地增进了我们对于共生微生物菌群如何影响宿主健康的理解。在宿主的各种致病性感染中，病毒感染构成了全球范围内最严重的公共卫生问题之一。在感染过程中，病毒可能与共生微生物菌群发生大量且密切的相互作用。大量证据表明，共生微生物菌群通过多种机制调节并反过来被入侵病毒所调节，从而在病毒感染中发挥刺激或抑制作用。此外，入侵病毒可能会破坏共生微生物菌群的完整性，导致宿主的微生态失调，并进一步影响病毒的感染力。在本文中，我们讨论了共生微生物菌群对病毒感染的调控的最新研究进展。我们还提请注意几种病毒对微生物组稳态的破坏。
