high expression associated with dysfunction in adult B-cell acute lymphoblastic leukemia.

The recombination mediated by recombination activating gene (RAG) is not only the dominant mutational process but also the predominant driver of oncogenic genomic rearrangement in acute lymphoblastic leukemia (ALL). It is further responsible for leukemic clonal evolution. In this study, significant increase is observed in the subsets of B-ALL patients, and high expression of is observed to be correlated with high proliferation markers. -encoded protein, IKAROS, directly binds to the promoter and regulates expression in leukemic cells. CK2 inhibitor by increasing IKAROS activity significantly suppresses expression in ALL in an IKAROS-dependent manner. Patients with deletion have significantly higher expression of compared to that without deletion. CK2 inhibitor treatment also results in an increase in binding to the promoter and suppression of expression in primary ALL cells. Taken together, these results demonstrate that high expression is associated with high proliferation markers in B-ALL. Our data for the first time proved that expression is directly suppressed by IKAROS. Our results also reveal drive oncogenesis of B-ALL is driven by high expression of with IKAROS dysfunction together, which have significance in an integrated prognostic model for adult ALL.