Palanimurugan A, Dhanalakshmi A, Selvapandian P, Kulandaisamy A
Department of Chemistry, Raja Doraisingam Government Arts College, Sivagangai, 630 561, Tamilnadu, India.
Department of Physics, Raja Doraisingam Government Arts College, Sivagangai, 630 561, Tamilnadu, India.
Heliyon. 2019 Jul 6;5(7):e02039. doi: 10.1016/j.heliyon.2019.e02039. eCollection 2019 Jul.
New tetradentate Schiff base transition metal complexes have been derived from salicylidene-4-imino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one and histidine were characterized by CHN analysis, magnetic susceptibility measurements, molar conductance, FAB-MS, IR, H-NMR, UV, CV, EPR, Fluorescence emission, AFM and Powder XRD techniques. AFM images and Powder XRD data endure that the complexes are nano-size grains with polycrystalline structure. The spectral evidences showed that all the metal chelates are square planar geometry except [VOL] complex which exist square-pyramidal geometry. Electrochemical data (CV) for [CuL] and [VOL] complexes in acetonitrile solution indicates that the redox potential of metal ions is affected by the coordinated ligand. Electron Spin Resonance (ESR) spectra of [CuL] and [VOL] complexes were well coinciding with proposed geometries and other reported complexes. CT-DNA interaction studies of [CuL] complex reveals that an intercalation binding mode occurs between complex and DNA base pairs. The antimicrobial activity of complexes has been tested against the growth of some fungal and bacterial species persist that chelates have better control than ligand.
新型四齿席夫碱过渡金属配合物由水杨醛-4-亚氨基-2,3-二甲基-1-苯基-3-吡唑啉-5-酮衍生而来，与组氨酸通过CHN分析、磁化率测量、摩尔电导率、FAB-MS、红外光谱、氢核磁共振、紫外光谱、循环伏安法、电子顺磁共振、荧光发射、原子力显微镜和粉末X射线衍射技术进行了表征。原子力显微镜图像和粉末X射线衍射数据表明，这些配合物是具有多晶结构的纳米尺寸颗粒。光谱证据表明，除了呈四方锥几何构型的[VOL]配合物外，所有金属螯合物均为平面正方形几何构型。[CuL]和[VOL]配合物在乙腈溶液中的电化学数据（循环伏安法）表明，金属离子的氧化还原电位受配位配体的影响。[CuL]和[VOL]配合物的电子自旋共振（ESR）光谱与提出的几何构型以及其他报道的配合物非常吻合。[CuL]配合物的CT-DNA相互作用研究表明，配合物与DNA碱基对之间存在插入结合模式。对配合物的抗菌活性针对一些真菌和细菌物种的生长进行了测试，结果表明螯合物比配体具有更好的控制效果。
