Han Liuqing, Li Ke, Xu Haitong, Mei Tao, Sun Yali, Qu Jingping, Song Yuming
State Key Laboratory of Fine Chemicals, School of Chemical Engineering , Dalian University of Technology , Dalian 116024 , P.R. China.
J Org Chem. 2019 Aug 16;84(16):10526-10534. doi: 10.1021/acs.joc.9b01488. Epub 2019 Aug 6.
Chiral-substituted 3-amino tetrahydro-2-pyran-2-ones were prepared in excellent enantioselectivities (up to 99% ee) via an organo-catalyzed cascade procedure with -TFA-Gly-Bt and α,β-unsaturated aldehydes as the substrates. The corresponding tetrahydro-2-pyran-2-ones can be used for further synthetic transformations that furnish chiral-substituted 3-aminopiperidin-2-ones with high levels of stereoselectivity.
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