Nishiyama M, Niimi K, Takagami S, Hirabayashi N, Yamaguchi M, Saeki T, Yoshinaka K, Wang D C, Niimoto M, Hattori T
Department of Surgery, Research Institute for Nuclear Medicine and Biology, Hiroshima University, Japan.
Jpn J Surg. 1988 Jan;18(1):93-7. doi: 10.1007/BF02470852.
In order to estimate the combined effects of UFT with other anticancer agents, a nude mouse experimental system (NMES), and a subrenal capsule assay (SRCA) were investigated. Three human tumor xenografts were serially transplanted into nude mice and examined. These were; EH-1 established from esophageal cancer, SH-6 from gastric cancer and CH-3 from colon cancer. The antiproliferative effects were estimated in accordance with the NCI therapeutic protocol. Significant antiproliferative effects were obtained only in NMES and a positive relationship was observed between the two assays (p less than 0.05). In the groups which were treated with a single agent, positive tumor responses were observed against mitomycin C in SH-6, against cis-DD platinum in SH-6 and EH-1, and against adriamycin in EH-1, respectively. On this study the synergistic, additive and subadditive effects were defined as the positive combined effects. The combination of MMC and UFT produced positive combined effects for all xenografts in both assays.
为了评估优福定（UFT）与其他抗癌药物的联合作用，对裸鼠实验系统（NMES）和肾包膜下接种法（SRCA）进行了研究。将三种人肿瘤异种移植物连续移植到裸鼠体内并进行检测。它们分别是：源自食管癌的EH - 1、源自胃癌的SH - 6和源自结肠癌的CH - 3。根据美国国立癌症研究所（NCI）的治疗方案评估抗增殖作用。仅在裸鼠实验系统中获得了显著的抗增殖作用，并且在两种检测方法之间观察到正相关关系（p小于0.05）。在单药治疗组中，分别观察到SH - 6对丝裂霉素C、SH - 6和EH - 1对顺二氨二氯铂以及EH - 1对阿霉素有阳性肿瘤反应。在本研究中，协同、相加和亚相加作用被定义为阳性联合作用。丝裂霉素C（MMC）与优福定的联合应用在两种检测方法中对所有异种移植物均产生了阳性联合作用。
