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临床医生对医院内抗菌药物管理计划的态度:来自巴基斯坦旁遮普省的一项多中心横断面研究。

Attitude of clinicians towards hospital-based antimicrobial stewardship programs: a multicenter cross-sectional study from Punjab, Pakistan.

机构信息

a Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xi'an Jiaotong University , Xi'an , China.

b Center for Drug Safety and Policy Research, Xi'an Jiaotong University , Xi'an , China.

出版信息

Expert Rev Anti Infect Ther. 2019 Aug;17(8):661-669. doi: 10.1080/14787210.2019.1647780. Epub 2019 Jul 31.

DOI:10.1080/14787210.2019.1647780
PMID:31335228
Abstract

: Antimicrobial resistance (AMR) is a major threat to global health and antimicrobial stewardship programs (ASPs) are useful to limit the momentum of AMR. This study was intended to determine the attitudes of clinicians about AMR, ASP strategies, and their readiness to participate in ASPs. : A cross-sectional survey was carried out among clinicians working in teaching hospitals of Punjab between August and November 2018. A multistage sampling method was used. Descriptive statistics and Kruskal-Wallis tests were employed for data analysis. : A response rate of 77.9% (670 ⁄ 859) was achieved. Most of the physicians (n = 302, 71.7%) compared to surgeons (n = 134, 70.9%) and anesthetists (n = 25, 41.7%) considered AMR as a serious health problem in Pakistani hospitals (p < 0.001). Clinicians were agreed that hospital audit and feedback (n = 434, 64.8%), restriction of certain antibiotics (n = 424, 63.3%), readily accessible microbiological data (n = 453, 67.6%), and regular educational sessions (n = 496, 74.0%) are imperative approaches to implement ASPs. Median ASP and AMR scores were significantly associated with age, experience, and types of clinicians (p < 0.05). : Despite poor previous knowledge of ASPs, all clinicians showed a positive attitude towards hospital ASPs. Several approaches suggested by clinicians will be helpful to implement hospital ASPs in Pakistan.

摘要

抗微生物药物耐药性(AMR)是对全球健康的主要威胁,抗微生物药物管理计划(ASPs)有助于限制 AMR 的势头。本研究旨在确定临床医生对抗微生物药物耐药性、ASPs 策略的态度及其参与 ASPs 的准备情况。

2018 年 8 月至 11 月,在旁遮普邦的教学医院中开展了一项横断面调查。采用多阶段抽样方法。采用描述性统计和 Kruskal-Wallis 检验进行数据分析。

我们获得了 77.9%(670 ⁄ 859)的应答率。与外科医生(n=134,70.9%)和麻醉师(n=25,41.7%)相比,大多数医生(n=302,71.7%)认为 AMR 是巴基斯坦医院的严重健康问题(p<0.001)。临床医生一致认为,医院审计和反馈(n=434,64.8%)、限制某些抗生素(n=424,63.3%)、方便获得微生物数据(n=453,67.6%)和定期教育课程(n=496,74.0%)是实施 ASPs 的必要方法。ASP 和 AMR 得分的中位数与年龄、经验和临床医生类型显著相关(p<0.05)。

尽管之前对抗微生物药物管理计划的了解有限,但所有临床医生对抗微生物药物管理计划都表现出积极的态度。临床医生提出的几种方法将有助于在巴基斯坦实施医院抗微生物药物管理计划。

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