Onder Ayse Busra, Guven Suleyman, Demir Selim, Mentese Ahmet, Guvendag Guven Emine Seda
Departments of Obstetric and Gynecology, Faculty of Medicine , Trabzon , Turkey.
Department of Nutrition and Dietetics, Faculty of Health Sciences , Trabzon , Turkey.
J Obstet Gynaecol. 2019 Nov;39(8):1160-1163. doi: 10.1080/01443615.2019.1604640. Epub 2019 Jul 23.
The aim of this study was to determine the serum biotin levels in patients with hyperemesis gravidarum (HG). Ninety pregnant women with HG (mild ( = 30), moderate ( = 30) and severe ( = 30)), and 80 pregnant women without HG were included for this study. In both groups, serum biotin levels were measured. There were no statistically significant differences in demographic and clinical characteristics between the HG groups and the control group except for PUQE scores. Serum biotin levels in all hyperemesis gravidarum groups were statistically significantly lower than control group. Negative statistically significant correlation between hyperemesis gravidarum severity and serum biotin levels was noted. This is the first study that shows low serum biotin levels in women with hyperemesis gravidarum. Impact statement Almost 80% of pregnant women have nausea and vomiting. If nausea and vomiting became severe and the symptoms combined with weight loss and ketonuria; the diagnosis should be hyperemesis gravidarum (HG). The etiopathogenetic factors of this unwanted condition have not been exactly known. Biotin is an essential water-soluble vitamin. Biotin catabolism increases in pregnancy. Marginal biotin deficiency occurs in approximately 50% of the gestations despite the "normal" biotin intake on the diet. Current study results elucidated that serum biotin levels were lower in HG cases compared to non HG cases. This study is the first study that reports the association between low serum level of biotin and HG. Further research is needed to show the importance of biotin supplementation in women with hyperemesis gravidarum.
本研究的目的是测定妊娠剧吐（HG）患者的血清生物素水平。本研究纳入了90例妊娠剧吐孕妇（轻度（=30）、中度（=30）和重度（=30））以及80例无妊娠剧吐的孕妇。两组均测定了血清生物素水平。除了PUQE评分外，妊娠剧吐组和对照组在人口统计学和临床特征方面没有统计学上的显著差异。所有妊娠剧吐组的血清生物素水平在统计学上均显著低于对照组。妊娠剧吐严重程度与血清生物素水平之间存在负相关。这是第一项显示妊娠剧吐女性血清生物素水平较低的研究。影响声明 近80%的孕妇有恶心和呕吐症状。如果恶心和呕吐变得严重，且症状伴有体重减轻和酮尿症，则应诊断为妊娠剧吐（HG）。这种不良情况的病因尚未完全明确。生物素是一种必需的水溶性维生素。孕期生物素分解代谢增加。尽管饮食中生物素摄入量“正常”，但约50%的妊娠期仍会出现边缘性生物素缺乏。目前的研究结果表明，与非妊娠剧吐病例相比，妊娠剧吐病例的血清生物素水平较低。本研究是第一项报道血清生物素水平低与妊娠剧吐之间关联的研究。需要进一步研究以表明生物素补充剂对妊娠剧吐女性的重要性。
