Department of Pathology, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon.
Department of Medicine, Yonsei University Graduate School.
Appl Immunohistochem Mol Morphol. 2020 Aug;28(7):544-550. doi: 10.1097/PAI.0000000000000795.
Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX) is involved in the epigenetic regulation. A previous mouse xenograft study revealed that UTX knockdown is associated with downregulated expression of matrix metalloproteinase-11 (MMP-11). The authors investigated 224 cases of breast cancer from Kangbuk Samsung Medical Center between 2000 and 2005. Nuclear UTX and cytoplasmic MMP-11 expressions were assessed using immunohistochemistry of tumor tissue microarray specimens. The relationships between the expression of UTX, MMP-11, and patients' outcomes were analyzed. UTX expression was significantly associated with high histologic grade, lymphatic invasion, vascular invasion, and tumoral expression of MMP-11. Survival analysis revealed that patients with UTX expression had a poorer overall survival rate (P=0.010) as well as diminished disease-free survival rate (P=0.001). The prognostic power of UTX expression was significant in patients with luminal-type breast cancer (P=0.027, overall survival; P=0.008, disease-free survival). Validation of UTX can provide further prognostic information beyond traditional indicators and represents a potential therapeutic target for breast cancer.
普遍转录四肽重复序列，X 染色体（UTX）参与表观遗传调控。先前的小鼠异种移植研究表明，UTX 敲低与基质金属蛋白酶-11（MMP-11）的下调表达有关。作者分析了 2000 年至 2005 年间来自康伯三星医疗中心的 224 例乳腺癌病例。使用肿瘤组织微阵列标本的免疫组织化学评估核 UTX 和细胞质 MMP-11 的表达。分析了 UTX、MMP-11 的表达与患者预后之间的关系。UTX 表达与高组织学分级、淋巴血管侵犯和肿瘤 MMP-11 表达显著相关。生存分析显示，UTX 表达的患者总生存率较差（P=0.010），无病生存率降低（P=0.001）。在 luminal 型乳腺癌患者中，UTX 表达的预后作用显著（P=0.027，总生存率；P=0.008，无病生存率）。UTX 的验证可以提供比传统指标更具预后意义的信息，并代表乳腺癌的潜在治疗靶点。
