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C反应蛋白与白蛋白比值在结直肠癌中的预后作用：一项荟萃分析

Prognostic role of C-reactive protein to albumin ratio in colorectal cancer: A meta analysis.

作者信息

Wang Fan, Li Pei, Li Feng-Sen

机构信息

Xinjiang Medical University, Urumqi.

Dushanzi People's Hospital, Kelamayi.

出版信息

Medicine (Baltimore). 2019 Jul;98(29):e16064. doi: 10.1097/MD.0000000000016064.

DOI:10.1097/MD.0000000000016064
PMID:31335668
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6709200/
Abstract

OBJECTIVE

This meta-analysis evaluates the prognosis value of C-reactive protein to albumin ratio (CAR) in colorectal cancer.

METHODS

Embase, PubMed, and Web of Science were searched. Pooled hazard ratios (HRs) with their corresponding 95% confidence intervals (CIs) were used as effective values.

RESULTS

A total of 6 studies with 1942 patients were included in this study. Pooled results revealed that elevated pretreatment CAR was related with poorer overall survival (OS) (HR: 2.09, 95%CI: 1.78-2.45, P < .001) in colorectal cancer.

CONCLUSION

Elevated CAR was associated with poor prognosis in colorectal cancer. Thus CAR might be used as a prognostic system and classification of colorectal patients in clinical potential.

摘要

目的

本荟萃分析评估C反应蛋白与白蛋白比值（CAR）在结直肠癌中的预后价值。

方法

检索了Embase、PubMed和Web of Science数据库。将合并的风险比（HRs）及其相应的95%置信区间（CIs）用作有效数值。

结果

本研究共纳入6项研究，涉及1942例患者。合并结果显示，结直肠癌患者治疗前CAR升高与较差的总生存期（OS）相关（HR：2.09，95%CI：1.78 - 2.45，P <.001）。

结论

CAR升高与结直肠癌的不良预后相关。因此，CAR在临床上可能用作结直肠癌患者的预后系统和分类指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1051/6709200/cc979feb7eb4/medi-98-e16064-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1051/6709200/0a10d146039a/medi-98-e16064-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1051/6709200/cf8f78ed1a41/medi-98-e16064-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1051/6709200/79d32ba6eb35/medi-98-e16064-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1051/6709200/d2fd519befb4/medi-98-e16064-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1051/6709200/cc979feb7eb4/medi-98-e16064-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1051/6709200/0a10d146039a/medi-98-e16064-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1051/6709200/cf8f78ed1a41/medi-98-e16064-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1051/6709200/79d32ba6eb35/medi-98-e16064-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1051/6709200/d2fd519befb4/medi-98-e16064-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1051/6709200/cc979feb7eb4/medi-98-e16064-g007.jpg

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