Junfeng Lu, Lina Ma, Xinyue Chen
International Medical Department, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Medicine (Baltimore). 2019 Jul;98(29):e16222. doi: 10.1097/MD.0000000000016222.
HIV-related lymphoma, especially non-Hodgkin lymphoma, is one of the most common malignant tumors in HIV/acquired immune deficiency syndrome (AIDS) patients. Autologous hematopoietic stem cell transplantation (AHSCT) for the patients with Burkitt lymphoma (BL) is needed to be further explored.
A 57-year-old man was hospitalized with intermittent pain on upper abdomen and melena for >1 month.
HIV antibody testing was positive. The upper gastrointestinal endoscopy was performed and histopathology and immunohistochemistry revealed BL.
Highly effective antiretroviral therapy and sixth cycles of chemotherapy were administered, followed by autologous hematopoietic stem cell transplantation.
The patient has had tumor-free survival for >6 years with normal CD4+ T cell counts and HIV viral load below the lowest detection LESSONS:: The patient was treated with AHSCT followed complete remission after chemotherapy and achieved long-term disease-free survival. AHSCT may be a promising way for clinical cure of HIV-related BL.
与HIV相关的淋巴瘤，尤其是非霍奇金淋巴瘤，是HIV/获得性免疫缺陷综合征（AIDS）患者中最常见的恶性肿瘤之一。伯基特淋巴瘤（BL）患者的自体造血干细胞移植（AHSCT）仍需进一步探索。
一名57岁男性因上腹部间歇性疼痛和黑便1个多月入院。
HIV抗体检测呈阳性。进行了上消化道内镜检查，组织病理学和免疫组化显示为BL。
给予高效抗逆转录病毒治疗和六个周期的化疗，随后进行自体造血干细胞移植。
患者无瘤生存超过6年，CD4+T细胞计数正常，HIV病毒载量低于最低检测值。
该患者接受AHSCT治疗，化疗后完全缓解，实现了长期无病生存。AHSCT可能是临床治愈HIV相关BL的一种有前景的方法。
