Becouarn Y, Brunet R, Bussières E, Marée D
Fondation Bergonié, Bordeaux, France.
Oncology. 1988;45(4):269-72. doi: 10.1159/000226620.
Fifteen patients, median age 64 years, presenting with advanced gastrointestinal adenocarcinomas, were included in this study. The treatment combination consisted of folinic acid (200 mg/m2, IV bolus injection) followed by 5-fluorouracil (5-FU; 400 mg/m2, 30-min infusion) for 5 consecutive days and mitomycin C (10 mg/m2, IV bolus injection) on day 1, the therapy being resumed every 21 days. An objective response was noted in 7 of 15 patients (47%): 1 complete and 6 partial responses, including 4 of 5 patients who had received no prior chemotherapy and 3 of 10 patients who previously failed to respond to 5-FU. Objective responses were encountered in 4 of 7 stomach cancers, 2 of 3 pancreas tumors, and in only 1 of 5 colorectal carcinomas. Furthermore, 9 of 11 patients were completely relieved of their abdominal pain. The median duration of remission was 5 months. The median survival time of patients who responded to treatment was 7 months. Toxicity was acceptable, with mainly leukopenia and/or thrombocytopenia (5 patients) and oral mucositis (3 patients), leading to dose reduction. The combination of 5-FU+ folinic acid + mitomycin C appears to be a potentially effective regimen in the treatment of advanced gastrointestinal tumors, even in patients previously treated with 5-FU.
本研究纳入了15例晚期胃肠道腺癌患者，中位年龄64岁。治疗方案为：先静脉推注亚叶酸钙（200mg/m²），随后连续5天静脉输注5-氟尿嘧啶（5-FU；400mg/m²，输注30分钟），第1天静脉推注丝裂霉素C（10mg/m²），每21天重复治疗。15例患者中有7例（47%）出现客观缓解：1例完全缓解，6例部分缓解，其中5例未接受过化疗的患者中有4例缓解，10例先前对5-FU治疗无效的患者中有3例缓解。7例胃癌患者中有4例、3例胰腺癌患者中有2例、5例结直肠癌患者中仅1例出现客观缓解。此外，11例患者中有9例腹痛完全缓解。缓解的中位持续时间为5个月。对治疗有反应的患者的中位生存时间为7个月。毒性反应可接受，主要为白细胞减少和/或血小板减少（5例患者）以及口腔黏膜炎（3例患者），导致剂量减少。5-FU + 亚叶酸钙 + 丝裂霉素C联合方案似乎是治疗晚期胃肠道肿瘤的一种潜在有效方案，即使是先前接受过5-FU治疗的患者。
