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Optimization of a single HPLC-PDA method for quantifying Metformin, Gliclazide, Pioglitazone, Dapagliflozin, Empagliflozin, Saxagliptin, Linagliptin and Teneligliptin using central composite design.

作者信息

Kant Ravi, Bodla Ramesh Babu, Kapoor Garima, Bhutani Rubina

机构信息

Pharmaceutical Chemistry Department, Delhi Institute of Pharmaceutical Sciences & Research, University of Delhi, Sector 3, Pushp Vihar, Mehrauli Badarpur Road, New Delhi 110017, India.

Pharmaceutical Chemistry Department, Delhi Institute of Pharmaceutical Sciences & Research, University of Delhi, Sector 3, Pushp Vihar, Mehrauli Badarpur Road, New Delhi 110017, India.

出版信息

Bioorg Chem. 2019 Oct;91:103111. doi: 10.1016/j.bioorg.2019.103111. Epub 2019 Jul 12.

DOI:10.1016/j.bioorg.2019.103111
PMID:31336308
Abstract
摘要

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1
Optimization of a single HPLC-PDA method for quantifying Metformin, Gliclazide, Pioglitazone, Dapagliflozin, Empagliflozin, Saxagliptin, Linagliptin and Teneligliptin using central composite design.使用中心复合设计优化一种用于定量测定二甲双胍、格列齐特、吡格列酮、达格列净、恩格列净、沙格列汀、利格列汀和替格列汀的高效液相色谱-光电二极管阵列检测（HPLC-PDA）单一方法。
Bioorg Chem. 2019 Oct;91:103111. doi: 10.1016/j.bioorg.2019.103111. Epub 2019 Jul 12.
2
Mean centering-triple divisor and ratio derivative-zero crossing for simultaneous determination of some diabetes drugs in their quaternary mixture with severely overlapping spectra.均值中心化三除数和比率导数过零点法用于同时测定严重重叠光谱的某些糖尿病药物的四元混合物。
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Application of experimental design in HPLC method optimization and robustness for the simultaneous determination of canagliflozin, empagliflozin, linagliptin, and metformin in tablet.实验设计在高效液相色谱法同时测定片剂中卡格列净、恩格列净、利格列汀和二甲双胍的方法优化及稳健性中的应用
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Validated Liquid Chromatographic Method for the Determination of (Canagliflozin, Dapagliflozin or Empagliflozin) and Metformin in the Presence of (1-Cyanoguanidine).用于在（1-氰基胍）存在下测定（卡格列净、达格列净或恩格列净）和二甲双胍的验证液相色谱法
J Chromatogr Sci. 2019 Aug 16;57(8):697-707. doi: 10.1093/chromsci/bmz042.
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Stability-indicating ultra performance liquid chromatography method development and validation for simultaneous estimation of metformin, linagliptin, and empagliflozin in bulk and pharmaceutical dosage form.用于同时测定 metformin、linagliptin 和 empagliflozin 原料药及其制剂的稳定性指示型超高效液相色谱法的开发与验证。
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Novel univariate spectrophotometric determination of the recently released solid dosage form comprising dapagliflozin and saxagliptin via factorized response spectra: Assessment of the average content and dosage unit uniformity of tablets.新型单变量分光光度法测定最近发布的包含达格列净和沙格列汀的固体制剂：片剂平均含量和单位剂量均匀度的评估。
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7
Bioequivalence and Food Effect of Dapagliflozin/Saxagliptin/Metformin Extended-release Fixed-combination Drug Products Compared With Coadministration of the Individual Components in Healthy Subjects.达格列净/沙格列汀/二甲双胍缓释固定剂量复方制剂与健康受试者中各成分合用的生物等效性和食物影响。
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Dual add-on therapy in type 2 diabetes poorly controlled with metformin monotherapy: a randomized double-blind trial of saxagliptin plus dapagliflozin addition versus single addition of saxagliptin or dapagliflozin to metformin.二甲双胍单药治疗血糖控制不佳的 2 型糖尿病的双联附加治疗：一项比较沙格列汀加达格列净双联附加治疗与沙格列汀或达格列净单药附加治疗加至二甲双胍的随机、双盲试验。
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9
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Dapagliflozin/saxagliptin (Qtern) for type 2 diabetes.达格列净/沙格列汀（Qtern）用于2型糖尿病。
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J Anal Methods Chem. 2021 May 11;2021:9983477. doi: 10.1155/2021/9983477. eCollection 2021.