白细胞介素-6产生增加促成妊娠期糖尿病的发展：一项印度研究。
Augmentation of IL-6 production contributes to development of gestational diabetes mellitus: An Indian study.
作者信息
Siddiqui Samreen, Waghdhare Swati, Goel Chhavi, Panda Manju, Soneja Hemi, Sundar Jayasree, Banerjee Meenakshi, Jha Sujeet, Dubey Shweta
机构信息
Institute of Endocrinology, Diabetes & Metabolism, Max Healthcare Inst. Ltd, Saket, New Delhi, 110017, India; Amity Institute of Virology & Immunology, Amity University Uttar Pradesh, Noida, Uttar Pradesh, 201313, India.
Institute of Endocrinology, Diabetes & Metabolism, Max Healthcare Inst. Ltd, Saket, New Delhi, 110017, India.
出版信息
Diabetes Metab Syndr. 2019 Mar-Apr;13(2):895-899. doi: 10.1016/j.dsx.2018.12.023. Epub 2018 Dec 27.
AIM
Inflammatory mediators like interleukin-6 (IL-6) and acute phase protein like C-reactive protein (CRP) are supposed to contribute to development of GDM, however clinical data supporting this hypothesis is limited. This study was designed to analyze the association of IL-6 and CRP with development of GDM in Indian females.
METHODS
This case control study included pregnant women diagnosed as GDM (n = 53) and those having normal glucose tolerance (n = 50). Serum levels of IL-6 and CRP were analysed and correlated with various clinical parameters.
RESULTS
Serum IL-6 levels were significantly high (p < 0.05) in GDM females as compared to control females. IL-6 levels correlated with pre-pregnancy body mass index (BMI), fasting blood sugar (FBS) and postprandial sugar (PPBS). Unlike IL-6, CRP levels did not show significant differences between GDM and control females. However, positive correlation of CRP levels with BMI, FBS and PPBS was observed.
CONCLUSION
High IL-6 levels in gestational diabetes may indicate a possible role for inflammation in pathophysiology of GDM.
目的
白细胞介素-6（IL-6）等炎症介质和C反应蛋白（CRP）等急性期蛋白被认为与妊娠期糖尿病（GDM）的发生有关，然而支持这一假设的临床数据有限。本研究旨在分析印度女性中IL-6和CRP与GDM发生的相关性。
方法
本病例对照研究纳入了被诊断为GDM的孕妇（n = 53）和糖耐量正常的孕妇（n = 50）。分析血清IL-6和CRP水平，并与各种临床参数进行相关性分析。
结果
与对照组女性相比，GDM女性的血清IL-6水平显著升高（p < 0.05）。IL-6水平与孕前体重指数（BMI）、空腹血糖（FBS）和餐后血糖（PPBS）相关。与IL-6不同，GDM和对照组女性的CRP水平没有显著差异。然而，观察到CRP水平与BMI、FBS和PPBS呈正相关。
结论
妊娠期糖尿病中IL-6水平升高可能表明炎症在GDM病理生理学中可能起作用。
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