Amirian Azam, Mahani Mahin Balouchi, Abdi Fatemeh
Department of Midwifery, School of Nursing and Midwifery, Jiroft University of Medical Sciences, Jiroft, Iran.
Social Determinants of Health Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Obstet Gynecol Sci. 2020 Jul;63(4):407-416. doi: 10.5468/ogs.20020. Epub 2020 Jul 1.
Gestational diabetes mellitus (GDM) is the most common pregnancy-associated metabolic disorder that is steadily increasing worldwide. Early diagnosis of pregnant women susceptible to GDM is the first step for deploying effective preventive treatment to reduce maternal, fetal, and neonatal complications. The diagnostic process of GDM is still controversial and interleukin-6 (IL-6) is one of the most recent markers used for the diagnosis of GDM. In this study, we aimed to systematically review the role of IL-6 in the diagnosis of GDM. In this systematic review, Google Scholar, Scopus, PubMed, ISI Web of Science, ProQuest, and MEDLINE databases were searched using the following keywords: GDM, screening, and IL-6, with the time interval 2009-2020. The quality of articles was assessed using the Strengthening the Reporting of Observational Studies in Epidemiology checklist. Twenty-four articles with desired quality that met the inclusion criteria were selected and reviewed further. Sixteen studies showed a statistically significant association, while 8 studies did not report any relationship between IL-6 levels and GDM. Based on the results of these studies, assessing the serum IL-6 levels can be investigated a newly established diagnostic biomarker for GDM. Therefore, through early diagnosis of susceptible women, effective measures can be implemented to reduce its complications.
妊娠期糖尿病（GDM）是最常见的妊娠相关代谢紊乱疾病，在全球范围内呈稳步上升趋势。对易患GDM的孕妇进行早期诊断是开展有效预防治疗以减少孕产妇、胎儿和新生儿并发症的第一步。GDM的诊断过程仍存在争议，白细胞介素-6（IL-6）是最近用于诊断GDM的标志物之一。在本研究中，我们旨在系统评价IL-6在GDM诊断中的作用。在这项系统评价中，使用以下关键词在谷歌学术、Scopus、PubMed、科学网ISI、ProQuest和MEDLINE数据库中进行检索：GDM、筛查和IL-6，时间跨度为2009年至2020年。使用流行病学观察性研究报告强化清单对文章质量进行评估。选择了24篇符合纳入标准且质量达标的文章并进行进一步审查。16项研究显示存在统计学显著关联，而8项研究未报告IL-6水平与GDM之间存在任何关系。基于这些研究结果，评估血清IL-6水平可作为一种新建立的GDM诊断生物标志物进行研究。因此，通过对易感女性进行早期诊断，可以采取有效措施减少其并发症。
