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缺氧在体外降低曲霉病的诊断生物标志物。

Hypoxia Decreases Diagnostic Biomarkers for Aspergillosis In Vitro.

作者信息

Maurer Elisabeth, Aigner Maria, Lass-Flörl Cornelia, Binder Ulrike

机构信息

Department of Hygiene, Medical Microbiology and Public Health, Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstrasse 41, 6020 Innsbruck, Austria.

出版信息

J Fungi (Basel). 2019 Jul 11;5(3):61. doi: 10.3390/jof5030061.

DOI:10.3390/jof5030061
PMID:31336719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6787614/
Abstract

The aim of the study was to evaluate the influence of hypoxia on galactomannan and (1,3)-β-d-glucan release of clinically relevant in vitro. Hypoxia decreased biomass and consequently led to lower biomarker release. However, when normalized to biomass, hypoxia led to increased levels of biomarkers at early growth stages (24 h). Antifungals (amphotericin B and voriconazole) decreased the galactomannan amount of , even more prominently in hypoxia.

摘要

该研究的目的是评估缺氧对临床相关体外半乳甘露聚糖和（1,3）-β-D-葡聚糖释放的影响。缺氧降低了生物量，因此导致生物标志物释放量降低。然而，以生物量进行标准化时，缺氧导致早期生长阶段（24小时）生物标志物水平升高。抗真菌药物（两性霉素B和伏立康唑）减少了的半乳甘露聚糖量，在缺氧条件下更为明显。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e35/6787614/c49189242e96/jof-05-00061-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e35/6787614/34fcfec31431/jof-05-00061-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e35/6787614/c49189242e96/jof-05-00061-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e35/6787614/34fcfec31431/jof-05-00061-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e35/6787614/c49189242e96/jof-05-00061-g002.jpg

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本文引用的文献

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Serum galactomannan-based early detection of invasive aspergillosis in hematology patients receiving effective antimold prophylaxis.血清半乳甘露聚糖检测在血液病患者接受有效抗真菌预防中侵袭性曲霉病的早期诊断。
Clin Infect Dis. 2014 Dec 15;59(12):1696-702. doi: 10.1093/cid/ciu673. Epub 2014 Aug 27.
2
Hypoxia enhances innate immune activation to Aspergillus fumigatus through cell wall modulation.缺氧通过细胞壁调节增强对烟曲霉的固有免疫激活。
Microbes Infect. 2013 Apr;15(4):259-69. doi: 10.1016/j.micinf.2012.11.010. Epub 2012 Dec 4.
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Hypoxia and fungal pathogenesis: to air or not to air?
缺氧与真菌致病机制：与空气有关还是无关？
Eukaryot Cell. 2012 May;11(5):560-70. doi: 10.1128/EC.00031-12. Epub 2012 Mar 23.
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Earlier response assessment in invasive aspergillosis based on the kinetics of serum Aspergillus galactomannan: proposal for a new definition.基于血清曲霉半乳甘露聚糖动力学的侵袭性曲霉病早期反应评估：新定义的建议。
Clin Infect Dis. 2011 Oct;53(7):671-6. doi: 10.1093/cid/cir441. Epub 2011 Aug 16.
5
In vivo hypoxia and a fungal alcohol dehydrogenase influence the pathogenesis of invasive pulmonary aspergillosis.体内缺氧和真菌醇脱氢酶影响侵袭性肺曲霉病的发病机制。
PLoS Pathog. 2011 Jul;7(7):e1002145. doi: 10.1371/journal.ppat.1002145. Epub 2011 Jul 21.
6
In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosis.体内生物发光成像和组织病理分析揭示了固有和募集的免疫效应细胞在防御侵袭性曲霉菌病方面的不同作用。
BMC Microbiol. 2010 Apr 8;10:105. doi: 10.1186/1471-2180-10-105.
7
Aspergillus fumigatus inhibits angiogenesis through the production of gliotoxin and other secondary metabolites.烟曲霉通过产生类毒素和其他次级代谢产物来抑制血管生成。
Blood. 2009 Dec 17;114(26):5393-9. doi: 10.1182/blood-2009-07-231209. Epub 2009 Oct 20.
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Interdependence of hypoxic and innate immune responses.缺氧反应与先天性免疫反应的相互依存关系。
Nat Rev Immunol. 2009 Sep;9(9):609-17. doi: 10.1038/nri2607.
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Bioluminescent Aspergillus fumigatus, a new tool for drug efficiency testing and in vivo monitoring of invasive aspergillosis.生物发光烟曲霉，一种用于药物疗效测试和侵袭性曲霉病体内监测的新工具。
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APMIS. 2007 Dec;115(12):1364-9. doi: 10.1111/j.1600-0463.2007.00719.x.