缺氧在体外降低曲霉病的诊断生物标志物。
Hypoxia Decreases Diagnostic Biomarkers for Aspergillosis In Vitro.
作者信息
Maurer Elisabeth, Aigner Maria, Lass-Flörl Cornelia, Binder Ulrike
机构信息
Department of Hygiene, Medical Microbiology and Public Health, Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstrasse 41, 6020 Innsbruck, Austria.
出版信息
J Fungi (Basel). 2019 Jul 11;5(3):61. doi: 10.3390/jof5030061.
Abstract
The aim of the study was to evaluate the influence of hypoxia on galactomannan and (1,3)-β-d-glucan release of clinically relevant in vitro. Hypoxia decreased biomass and consequently led to lower biomarker release. However, when normalized to biomass, hypoxia led to increased levels of biomarkers at early growth stages (24 h). Antifungals (amphotericin B and voriconazole) decreased the galactomannan amount of , even more prominently in hypoxia.
摘要
该研究的目的是评估缺氧对临床相关体外半乳甘露聚糖和（1,3）-β-D-葡聚糖释放的影响。缺氧降低了生物量，因此导致生物标志物释放量降低。然而，以生物量进行标准化时，缺氧导致早期生长阶段（24小时）生物标志物水平升高。抗真菌药物（两性霉素B和伏立康唑）减少了的半乳甘露聚糖量，在缺氧条件下更为明显。
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