Orikasa S, Sloley B D
Neuropsychiatric Research Unit, University of Saskatchewan, Saskatoon, Canada.
Psychopharmacology (Berl). 1988;95(1):124-31. doi: 10.1007/BF00212780.
Head-twitch response (HTR) in mice was induced by intracerebroventricular injection of tryptamine (TRA) as well as serotonin (5-HT) and p-chloroamphetamine (PCA). Pretreatment with 5,7-dihydroxytryptamine enhanced both the 5-HT-induced and the TRA-induced HTR. The PCA-induced HTR, however, was attenuated by the drug. On the other hand, pretreatment with 6-hydroxydopamine did not alter the 5-HT response but enhanced both the PCA- and the TRA-induced response. These results suggest that 5-HT may directly stimulate the post-synaptic receptors, while the PCA response may be based on the release of endogenous 5-HT. The presynaptic component of the central serotonergic system does not appear to be involved in the TRA response. Both PCA and TRA may affect catecholaminergic systems which can suppress the response.
通过脑室内注射色胺（TRA）以及血清素（5-HT）和对氯苯丙胺（PCA）诱导小鼠的头部抽搐反应（HTR）。用5,7-二羟基色胺预处理可增强5-HT诱导的和TRA诱导的HTR。然而，PCA诱导的HTR被该药物减弱。另一方面，用6-羟基多巴胺预处理不会改变5-HT反应，但会增强PCA和TRA诱导的反应。这些结果表明，5-HT可能直接刺激突触后受体，而PCA反应可能基于内源性5-HT的释放。中枢5-羟色胺能系统的突触前成分似乎不参与TRA反应。PCA和TRA都可能影响可抑制该反应的儿茶酚胺能系统。
