Carideo Luciano, Prosperi Daniela, Panzuto Francesco, Magi Ludovica, Pratesi Maria Sole, Rinzivillo Maria, Annibale Bruno, Signore Alberto
Nuclear Medicine Unit, ENETS Center of Excellence, Sant'Andrea University Hospital, 00189 Rome, Italy.
Digestive Disease Unit, ENETS Center of Excellence, Sant'Andrea University Hospital, 00189 Rome, Italy.
J Clin Med. 2019 Jul 13;8(7):1032. doi: 10.3390/jcm8071032.
Gastro-entero-pancreatic neuroendocrine neoplasia (GEP-NENs) are rare tumors, but their frequency is increasing. Neuroendocrine tumors normally express somatostatin (SST) receptors (SSTR) on cell surface, especially G1 and G2 stage tumors, but they can show a dedifferentiation in their clinical history as they become more aggressive. Somatostatin receptor imaging has previously been performed with a gamma camera using [In]In or [Tc]Tc-labelled compounds, while [Ga]Ga-labelled compounds and PET/CT imaging has recently become the gold standard for the diagnosis and management of these tumors. Moreover, in the last few years F-fluorodeoxyglucose ([F]FDG) PET/CT has emerged as an important tool to define tumor aggressiveness and give relevant prognostic information, particularly when coupled with [Ga]Ga-labelled SST analogues PET/CT. This review focuses on the importance of combined imaging with [Ga]Ga-labelled SST analogues and [F]FDG for the management of GEP-NENs.
胃肠胰神经内分泌肿瘤（GEP-NENs）是罕见肿瘤，但其发病率正在上升。神经内分泌肿瘤通常在细胞表面表达生长抑素（SST）受体（SSTR），尤其是G1和G2期肿瘤，但随着病情进展、侵袭性增强，它们在临床过程中可能会出现去分化。生长抑素受体显像以前是使用γ相机，采用[铟]铟或[锝]锝标记的化合物进行，而[镓]镓标记的化合物及PET/CT显像最近已成为这些肿瘤诊断和管理的金标准。此外，在过去几年中，氟脱氧葡萄糖（[F]FDG）PET/CT已成为确定肿瘤侵袭性并提供相关预后信息的重要工具，特别是与[镓]镓标记的SST类似物PET/CT联合使用时。本综述重点关注[镓]镓标记的SST类似物与[F]FDG联合显像在GEP-NENs管理中的重要性。
