Clinical experience with antidepressive infusion therapy: trazodone.

The tolerance and efficacy of trazodone were studied in subjects between 20 and 70 years of age. The first step was to conduct an open trial. Each patient (in- and out-patients) received increasing doses (range 25 mg-200 mg/day/2h) for a period of 10 days. Disorders diagnosed as depressive were classified by ICD-9. Blood-pressure and pulse rate were determined before and after infusion. The side effects (TWIS), Hamilton Depression Scale (HAMD), Depression Self Rating Scale (DS v. Zehrssen), and Clinical Global Impression (CGI) were assumed after medication. The results are demonstrated.