Preisig P A, Toto R D, Alpern R J
University of Texas Southwestern Medical Center, Department of Internal Medicine, Dallas.
Ren Physiol. 1987;10(3-4):136-59. doi: 10.1159/000173126.
The purpose of the present review is to describe the use of carbonic anhydrase inhibitors in clinical medicine and renal physiology. We first describe the localization of carbonic anhydrase within the kidney and then discuss evidence for its role in renal acidification and NaCl absorption. This is then followed by a description of clinical uses for carbonic anhydrase inhibitors. Many of the uses and effects of carbonic anhydrase inhibitors can be predicted from an understanding of renal physiology and the role of carbonic anhydrase. The limited potency of carbonic anhydrase inhibitors correlates well with the large magnitude of carbonic anhydrase-independent bicarbonate absorption. While theories for carbonic anhydrase-independent bicarbonate absorption are presented, the exact mechanisms remain unresolved.
本综述的目的是描述碳酸酐酶抑制剂在临床医学和肾脏生理学中的应用。我们首先描述碳酸酐酶在肾脏内的定位，然后讨论其在肾脏酸化和氯化钠重吸收中作用的证据。接下来描述碳酸酐酶抑制剂的临床用途。从对肾脏生理学和碳酸酐酶作用的理解中，可以预测出碳酸酐酶抑制剂的许多用途和效果。碳酸酐酶抑制剂的效力有限，这与不依赖碳酸酐酶的大量碳酸氢盐重吸收密切相关。虽然提出了不依赖碳酸酐酶的碳酸氢盐重吸收的理论，但确切机制仍未解决。
