The differentiation between constitutional delayed puberty and hypogonadotropic hypogonadism: experience with three newly devised methods.

There is no known method that is wholly successful in differentiating between hypogonadotropic hypogonadism and constitutional delayed puberty at an early stage. We present here the results we have got with three recently suggested methods in patients with delayed and absent puberty. These methods are te LHRH test before and after 36 hour pulsatile LHRH treatment, the prolactin response to TRH, and the prolactin response to metoclopramide.