对硝基苯乙酮与鸟苷一磷酸之间的三重态电荷转移反应：电子亲和性放射增敏的一种可能机制。
The triplet-state charge-transfer reaction between p-nitroacetophenone and guanosine monophosphate: a possible mechanism for electron-affinic radiosensitization.
作者信息
Smith G J
出版信息
Int J Radiat Biol Relat Stud Phys Chem Med. 1979 Mar;35(3):265-71. doi: 10.1080/09553007914550301.
Using flash photolysis it has been observed that the triplet state of p-nitroacetophenone reacts rapidly with guanosine monophosphate to give the p-nitroacetophenone radical anion, and presumably the guanine radical cation is also formed in this reaction. From this observation, it is predicted by theory that a similar reaction will occur between p-nitroacetophenone and the triplet state of guanosine monophosphate. Because guanine is excited to its triplet state when DNA is irradiated with X-rays, it is suggested that the charge transfer reaction between p-nitroacetophenone and the triplet state of guanine contributes to the radiosensitizing action of p-nitroacetophenone.
通过闪光光解观察到，对硝基苯乙酮的三重态与鸟苷一磷酸迅速反应，生成对硝基苯乙酮自由基阴离子，并且据推测，该反应中还会形成鸟嘌呤自由基阳离子。基于这一观察结果，理论预测对硝基苯乙酮与鸟苷一磷酸的三重态之间会发生类似反应。由于用X射线照射DNA时鸟嘌呤会被激发到三重态，因此有人提出，对硝基苯乙酮与鸟嘌呤三重态之间的电荷转移反应有助于对硝基苯乙酮的放射增敏作用。
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