基底膜和血脑屏障。
Basement membrane and blood-brain barrier.
机构信息
Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia, USA.
出版信息
Stroke Vasc Neurol. 2018 Dec 5;4(2):78-82. doi: 10.1136/svn-2018-000198. eCollection 2019 Jul.
The blood-brain barrier (BBB) is a highly complex and dynamic structure, mainly composed of brain microvascular endothelial cells, pericytes, astrocytes and the basement membrane (BM). The vast majority of BBB research focuses on its cellular constituents. Its non-cellular component, the BM, on the other hand, is largely understudied due to its intrinsic complexity and the lack of research tools. In this review, we focus on the role of the BM in BBB integrity. We first briefly introduce the biochemical composition and structure of the BM. Next, the biological functions of major components of the BM in BBB formation and maintenance are discussed. Our goal is to provide a concise overview on how the BM contributes to BBB integrity.
血脑屏障（BBB）是一个高度复杂和动态的结构，主要由脑微血管内皮细胞、周细胞、星形胶质细胞和基底膜（BM）组成。绝大多数 BBB 的研究都集中在其细胞成分上。另一方面，由于其内在的复杂性和缺乏研究工具，其非细胞成分 BM 则在很大程度上未被充分研究。在这篇综述中，我们专注于 BM 在 BBB 完整性中的作用。我们首先简要介绍 BM 的生化组成和结构。接下来，讨论了 BM 中的主要成分在 BBB 形成和维持中的生物学功能。我们的目标是提供一个关于 BM 如何有助于 BBB 完整性的简洁概述。
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