INSERM, U908, 59000, Lille, France.
Univ. Lille, U908 - CPAC - Cell plasticity and Cancer, 59000, Lille, France.
Cell Mol Life Sci. 2019 Dec;76(23):4673-4687. doi: 10.1007/s00018-019-03240-z. Epub 2019 Jul 23.
Cancer cells exhibit hallmarks in terms of proliferation, resistance to cell death, angiogenesis, invasion, metastasis, and genomic instability. Despite the progress in cancer research and the comprehension of tumorigenesis mechanisms, cancer remains a major issue in public health. A better understanding of the molecular factors associated with the appearance or progression of cancer may allow the development of therapeutic alternatives. Increasing data highlight the role of long non-coding RNAs in many diseases, including cancer. The long non-coding RNA H19 was the first discovered riboregulator, and it has been shown to be involved at multiple steps of tumorigenesis. Indeed, this lncRNA exert its action at various molecular scales. Understanding the role of H19 in cancer progression may allow to set up therapeutic strategies to prevent tumor expansion and metastatic dissemination. In this review, we will summarize the overexpression of the long non-coding RNA H19 in several types of cancer and the multiple implications of the long non-coding RNA H19 in the different hallmarks that define human cancer.
癌细胞在增殖、抵抗细胞死亡、血管生成、侵袭、转移和基因组不稳定性方面表现出特征。尽管癌症研究取得了进展，对肿瘤发生机制的理解也有所加深，但癌症仍然是公共卫生的一个主要问题。更好地了解与癌症出现或进展相关的分子因素可能会为开发治疗方法提供新的选择。越来越多的数据强调了长非编码 RNA 在包括癌症在内的许多疾病中的作用。长非编码 RNA H19 是第一个被发现的核糖调节因子，它已被证明参与了肿瘤发生的多个步骤。事实上，这种长非编码 RNA 在多个分子尺度上发挥作用。了解 H19 在癌症进展中的作用可能有助于制定治疗策略来防止肿瘤的扩张和转移扩散。在这篇综述中，我们将总结长非编码 RNA H19 在几种类型的癌症中的过表达，以及长非编码 RNA H19 在定义人类癌症的不同特征中的多种作用。
