Department of Biology, TAMU 3258 Texas A&M, College Station, TX, 77843, USA.
Department of Biology, University of Texas at Arlington, 501 S. Nedderman Dr, Arlington, TX, 76019, USA.
Chromosome Res. 2019 Dec;27(4):313-319. doi: 10.1007/s10577-019-09613-1. Epub 2019 Jul 23.
One of the first characteristics that we learn about the genome of many species is the number of chromosomes it is divided among. Despite this, many questions regarding the evolution of chromosome number remain unanswered. Testing hypotheses of chromosome number evolution using comparative approaches requires trait data to be readily accessible and associated with currently accepted taxonomy. The lack of accessible karyotype data that can be linked to phylogenies has limited the application of comparative approaches that could help us understand the evolution of genome structure. Furthermore, for taxonomists, the significance of new karyotype data can only be determined with reference to records for other species. Here, we describe a curated database (karyotype.org) developed to facilitate access to chromosome number and sex chromosome system data for amphibians. The open web interface for this database allows users to generate customized exploratory plots and tables of selected clades, as well as downloading CSV files for offline analyses.
我们首先了解到的关于许多物种基因组的特征之一是它在染色体中被划分的数量。尽管如此，关于染色体数量进化的许多问题仍然没有答案。使用比较方法检验染色体数量进化的假设，需要可随时获得的特征数据，并与当前公认的分类学相关联。缺乏可与系统发育联系起来的可访问的染色体组型数据，限制了有助于我们了解基因组结构进化的比较方法的应用。此外，对于分类学家来说，新的染色体组型数据的意义只能通过参考其他物种的记录来确定。在这里，我们描述了一个经过精心整理的数据库（karyotype.org），用于方便获取两栖动物的染色体数量和性染色体系统数据。该数据库的开放网络界面允许用户生成选定进化枝的自定义探索性图和表，以及下载 CSV 文件进行离线分析。
