葡萄糖代谢紊乱患者听力功能的改变。

Alterations in hearing function of patients with glucose disorders.

机构信息

Department of Endocrinology and Metabolic Diseases, University Hospital, School of Medicine, University of Thessaly, Biopolis, Larissa, Greece.

Division of Endocrinology and Diabetes, "Aghia Sophia" Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

出版信息

Hormones (Athens). 2019 Sep;18(3):281-287. doi: 10.1007/s42000-019-00120-w. Epub 2019 Jul 23.

DOI:10.1007/s42000-019-00120-w

PMID:31338751

Abstract

OBJECTIVE

To study the prevalence of hearing impairment in patients with various glucose disorders.

PATIENTS AND METHODS

A total of 499 individuals were studied, 51 patients with type 1 (TIDM), 188 patients with type 2 diabetes mellitus (T2DM), 39 patients with impaired fasting glucose (IFG), and 221 controls. Measurements were performed, blood was drawn, and a relevant questionnaire was completed. Ηearing function was assessed by pure-tone audiometry (PTA) and distortion product otoacustic emissions (DPOAEs).

RESULTS

Patients with impaired glucose metabolism (IGM: T2DM or IFG) compared to controls had a higher percentage of abnormal PTA and DPOAEs for both the right (70.2 vs. 56.9% and 40.4 vs. 24.2%, respectively, p < 0.001) and the left (74.1 vs. 59.3% and 47.5 vs. 25.4%, respectively, p < 0.001) ear. Patients with TIDM had similar levels for the left ear (54.9 vs. 59.3% and 27.5 vs. 25.4%, respectively, p > 0.05) and lower levels for the right ear (35.3 vs. 56.9% and 13.7 vs. 24.2%, respectively, p < 0.001 and p = 0.044) percentages of abnormal PTA and DPOAEs compared to controls. Logistic regression analysis indicated that independent parameters for abnormal DPOAEs in one or both ears are age, male gender, exposure to noisy environments, and the presence of IGM.

CONCLUSIONS

Hearing impairment was more prevalent in patients with IGM compared to healthy controls, as assessed by PTA and DPOAEs. Age, male gender, and exposure to noise are other factors that can independently affect hearing ability. Physicians should bear in mind possible defects in hearing ability when dealing with such patients.

摘要

目的

研究各种糖代谢紊乱患者听力障碍的患病率。

患者和方法

共研究了 499 人，其中 51 例 1 型糖尿病（TIDM）患者、188 例 2 型糖尿病患者（T2DM）、39 例空腹血糖受损（IFG）患者和 221 例对照组。进行了测量、采血并完成了相关问卷。听力功能通过纯音听阈（PTA）和畸变产物耳声发射（DPOAE）进行评估。

结果

与对照组相比，葡萄糖代谢受损（IGM：T2DM 或 IFG）患者的右耳（70.2%比 56.9%和 40.4%比 24.2%，均 p<0.001）和左耳（74.1%比 59.3%和 47.5%比 25.4%，均 p<0.001）的 PTA 和 DPOAE 异常比例更高。TIDM 患者左耳的水平相似（54.9%比 59.3%和 27.5%比 25.4%，均 p>0.05），而右耳的水平较低（35.3%比 56.9%和 13.7%比 24.2%，均 p<0.001 和 p=0.044）。与对照组相比，PTA 和 DPOAE 的异常率更高。Logistic 回归分析表明，双耳或单耳 DPOAE 异常的独立参数为年龄、男性、接触噪声环境和 IGM 存在。