College of Chemistry and Chemical Engineering , Xinyang Normal University , Xinyang , Henan 464000 , China.
College of Chemistry and Molecular Engineering , Zhengzhou University , Zhengzhou , Henan 450001 , China.
Org Lett. 2019 Aug 2;21(15):5995-5999. doi: 10.1021/acs.orglett.9b02131. Epub 2019 Jul 24.
A transition-metal-free and environmentally friendly synthesis method for bromobenzothiazines through tandem C-H amination/bromination was reported. This reaction contains both intramolecular C-H amination and site-selective electrophilic bromination of arenes with NaBr as the bromo source, PhI(OAc) or KSO as the oxidant, and HO as the only solvent.
本文报道了一种通过串联 C-H 氨化/溴化反应实现溴苯并噻嗪的无过渡金属、环境友好合成方法。该反应以 NaBr 作为溴源、PhI(OAc)或 KSO 作为氧化剂、HO 作为唯一溶剂，包含分子内 C-H 氨化和芳基的选择性亲电溴化。
