Institute of Science and Technology Austria (IST Austria), Klosterneuburg, 3400, Austria.
Evolution. 2019 Sep;73(9):1729-1745. doi: 10.1111/evo.13812. Epub 2019 Aug 16.
This article analyzes how partial selfing in a large source population influences its ability to colonize a new habitat via the introduction of a few founder individuals. Founders experience inbreeding depression due to partially recessive deleterious alleles as well as maladaptation to the new environment due to selection on a large number of additive loci. I first introduce a simplified version of the inbreeding history model to characterize mutation-selection balance in a large, partially selfing source population under selection involving multiple nonidentical loci. I then use individual-based simulations to study the eco-evolutionary dynamics of founders establishing in the new habitat under a model of hard selection. The study explores how selfing rate shapes establishment probabilities of founders via effects on both inbreeding depression and adaptability to the new environment, and also distinguishes the effects of selfing on the initial fitness of founders from its effects on the long-term adaptive response of the populations they found. A high rate of (but not complete) selfing is found to aid establishment over a wide range of parameters, even in the absence of mate limitation. The sensitivity of the results to assumptions about the nature of polygenic selection is discussed.
本文分析了在一个大型源种群中部分自交如何影响其通过引入少数创始个体来殖民新栖息地的能力。由于部分隐性有害等位基因以及由于大量加性位点的选择而导致对新环境的不适应，创始人经历了近交衰退。我首先引入了一个简化的近亲繁殖历史模型，以描述在涉及多个非同源基因座的选择下，一个大型部分自交源种群中的突变选择平衡。然后，我使用基于个体的模拟来研究在硬选择模型下，在新栖息地建立的创始人的生态进化动态。该研究通过对近交衰退和对新环境的适应性的影响来探讨自交率如何影响创始人的建立概率，并区分自交对创始人初始适应性的影响与其对其建立的种群的长期适应性反应的影响。即使在不存在配偶限制的情况下，也发现高（但不完全）的自交率有助于在广泛的参数范围内建立。还讨论了对多基因选择性质的假设的敏感性。
