Khandare Jayant, Ds Madhusudhan, Ananthan Anitha, Nanavati Ruchi
Department of Neonatology, Seth GS Medical College and King Edward Memorial Hospital, Mumbai, India.
J Trop Pediatr. 2020 Apr 1;66(2):194-200. doi: 10.1093/tropej/fmz051.
This retrospective audit aimed to analyze whether routine frequent monitoring for hypoglycemia is required in asymptomatic infant of diabetic mother born in tertiary care hospital.
The study analyzed the blood sugar level of 196 infants of diabetic mothers.
The overall incidence of hypoglycemia from 196 study participants was 9.18% (N = 18). The incidence of hypoglycemia at 2 h of life was maximum (83.33%) and it was significant when compared to 3, 6, 9 and 12 h (p < 0.0001). Blood glucose levels were significantly more at 6 (p = 0.0002)), 9 (p = 0.0001) and 12 h (p = 0.0001) when compared to glucose level at 2 h except at 3 h of life (p = 0.062). Similarly blood glucose at 9 (p = 0.0001) and 12 h of life (p = 0.0002) were significantly more than at 3 h of life. Blood glucose at 9 h was significantly more than at 6 h of life (0.032) and at 12 hours of life (p = 0.0237) was significantly higher than at 6 h of life.
The frequent blood glucose monitoring for hypoglycemia in infant of diabetic mother as per American Academy of Pediatrics may be reduced as per the findings in our study. However, this needs to be confirmed by a properly designed observational study/adequately powered randomized controlled trial.
本回顾性审计旨在分析在三级护理医院出生的糖尿病母亲的无症状婴儿是否需要进行常规频繁的低血糖监测。
该研究分析了196例糖尿病母亲的婴儿的血糖水平。
196名研究参与者中低血糖的总体发生率为9.18%(N = 18)。出生后2小时低血糖的发生率最高(83.33%),与3、6、9和12小时相比具有显著性差异(p < 0.0001)。与出生后2小时的血糖水平相比,除出生后3小时(p = 0.062)外,出生后6小时(p = 0.0002)、9小时(p = 0.0001)和12小时(p = 0.0001)的血糖水平显著更高。同样,出生后9小时(p = 0.0001)和12小时(p = 0.0002)的血糖水平显著高于出生后3小时。出生后9小时的血糖水平显著高于出生后6小时(0.032),出生后12小时(p = 0.0237)的血糖水平显著高于出生后6小时。
根据我们的研究结果,按照美国儿科学会的建议对糖尿病母亲的婴儿进行频繁的低血糖血糖监测可能会减少。然而,这需要通过精心设计的观察性研究/有足够效力的随机对照试验来证实。