Laboratoire LR11ES41 Génétique Biodiversité et Valorisation des Bio-ressources, Institut Supérieur de Biotechnologie de Monastir, Université de Monastir, Monastir, Tunisie.
Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.
J Pineal Res. 2019 Oct;67(3):e12597. doi: 10.1111/jpi.12597. Epub 2019 Aug 19.
Melatonin (MLT) plays a role in preserving bone health, a function that may depend on homeostatic effects on both mature osteoblasts and mesenchymal stem cells (MSCs) of the bone tissue. In this study, these functions of MLT have been investigated in rat bone (femur) and in human adipose MSC (hMSC) during chronic exposure to low-grade cadmium (Cd) toxicity, a serious public health concern. The in vivo findings demonstrate that MLT protects against Cd-induced bone metabolism disruption and accumulation of bone marrow adipocytes, a cue of impaired osteogenic potential of skeletal MSC niches. This latter symptom was recapitulated in hMSCs in which Cd toxicity stimulated adipogenic differentiation. MLT was found to rescue, at least in part, the osteogenic differentiation properties of these cells. This study reports on a new bone cytoprotection function of MLT pertinent to Cd toxicity and its interfering effect on skeletal MSC differentiation properties that is worth investigating for its possible impact on human bone pathophysiology.
褪黑素 (MLT) 在维持骨骼健康方面发挥作用，其功能可能取决于对成熟成骨细胞和骨骼组织间充质干细胞 (MSC) 的稳态影响。在这项研究中，研究了 MLT 在慢性低浓度镉 (Cd) 毒性暴露下对大鼠骨骼（股骨）和人脂肪间充质干细胞 (hMSC) 的这些功能，这是一个严重的公共卫生问题。体内研究结果表明，MLT 可防止 Cd 诱导的骨代谢紊乱和骨髓脂肪细胞堆积，这是骨骼 MSC 龛位成骨潜能受损的一个迹象。在 Cd 毒性刺激成脂分化的 hMSCs 中重现了这一症状。发现 MLT 至少部分挽救了这些细胞的成骨分化特性。本研究报告了 MLT 的一种新的骨细胞保护功能，与 Cd 毒性及其对骨骼 MSC 分化特性的干扰作用有关，值得研究其对人类骨病理生理学的可能影响。
