Zhang Yongjun, Yang Tao, Zhou Wenjiao, Huang Yuee
Department of Electrocardiograph, Yijishan Hospital of Wannan Medical College, Wuhu 241001, China.
School of Public Health, Wannan Medical College, Wuhu 241002, China.
Rev Assoc Med Bras (1992). 2019 Jul 22;65(6):923-929. doi: 10.1590/1806-9282.65.6.923.
To investigate the association between genotype insertion or deletion polymorphism of the angiotensin-converting enzyme gene (ACE) and susceptibility to coronary artery disease (CAD) in Chinese Han population.
We conducted a comprehensive search for the OR value of contrast between the group of genotype insertion or deletion polymorphism of the ACE and the group of CAD as an effective index. A meta-analysis (Stata 12.0) was used to test the heterogeneity of the results, combine the values for effect, conduct sensitivity analysis, and basic evaluation.
A total of 638 studies were found on the association between polymorphisms of the angiotensin-converting enzyme gene and CAD, of which 44 studies met the inclusion criteria. In total, our study included 5619 cases and 4865 controls. The heterogeneity test of each study (P < 0.001) was carried out using a random effect model. The OR value of DD/ID+II was 1.95, 95% confidence interval (95%CI) (1.66-2.29). The OR value of II/DI+DD was 0.63, 95%CI (0.55-0.72). The funnel figure is basically symmetrical and the results of the sensitivity analysis were stable.
The DD genotype of the angiotensin converting enzyme gene may be a weaker risk factor for CAD in the Chinese Han population.
探讨血管紧张素转换酶基因（ACE）插入/缺失多态性与中国汉族人群冠状动脉疾病（CAD）易感性之间的关联。
全面检索ACE基因插入/缺失多态性组与CAD组之间对比的OR值作为有效指标。采用Meta分析（Stata 12.0）检验结果的异质性，合并效应值，进行敏感性分析和基本评价。
共检索到638项关于血管紧张素转换酶基因多态性与CAD关联的研究，其中44项研究符合纳入标准。本研究共纳入5619例病例和4865例对照。采用随机效应模型对各研究进行异质性检验（P<0.001）。DD/ID+II的OR值为1.95，95%置信区间（95%CI）为（1.66 - 2.29）。II/DI+DD的OR值为0.63，95%CI为（0.55 - 0.72）。漏斗图基本对称，敏感性分析结果稳定。
血管紧张素转换酶基因的DD基因型可能是中国汉族人群CAD的较弱危险因素。
