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由班替枝孢霉引起的皮下暗色丝孢霉病:拉丁美洲首例免疫功能正常患者病例报告及文献综述

Subcutaneous phaeohyphomycosis due to Cladophialophora bantiana: a first case report in an immunocompetent patient in Latin America and a brief literature review.

作者信息

Maquiné Gustavo Ávila, Rodrigues Marcos Henrique Gurgel, Schettini Antônio Pedro Mendes, Morais Patricia Motta de, Frota Maria Zeli Moreira

机构信息

Ambulatório de Dermatologia, Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta, Manaus, AM, Brasil.

Laboratório de Micologia Clínica, Faculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas, Manaus, AM, Brasil.

出版信息

Rev Soc Bras Med Trop. 2019 Jul 18;52:e20180480. doi: 10.1590/0037-8682-0480-2018.

Abstract

We report a rare case of subcutaneous phaeohyphomycosis caused by Cladophialophora bantiana in an immunocompetent patient in Amazonas, Brazil. This dematiaceous fungus has been mainly associated with life-threatening infections affecting the central nervous systems of immunosuppressed patients. We present the clinical, laboratory, and therapeutic aspects, and in vitro susceptibility test results for different antifungal drugs. A brief review of the cases reported in the literature over the past 20 years has also been discussed. According to the literature review, the present case is the first report of subcutaneous phaeohyphomycosis due to C. bantiana in an immunocompetent patient in Latin America.

摘要

我们报告了巴西亚马孙地区一名免疫功能正常患者发生的由班替枝孢霉引起的罕见皮下暗色丝孢霉病病例。这种暗色真菌主要与影响免疫抑制患者中枢神经系统的危及生命的感染有关。我们介绍了临床、实验室和治疗方面的情况,以及不同抗真菌药物的体外药敏试验结果。还讨论了对过去20年文献报道病例的简要回顾。根据文献回顾,本病例是拉丁美洲免疫功能正常患者中首例由班替枝孢霉引起的皮下暗色丝孢霉病报告。

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