钯催化二芳基碘代物与二茂铁羧酸的 C-H 芳基化反应。
Palladium-Catalyzed C-H Diarylation of Ferrocenecarboxylic Acids with Aryl Iodides.
机构信息
State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry , Chinese Academy of Sciences , 345 Lingling Lu , Shanghai 200032 , China.
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry , Central China Normal University , Wuhan 430079 , China.
出版信息
J Org Chem. 2019 Oct 18;84(20):13144-13149. doi: 10.1021/acs.joc.9b01503. Epub 2019 Aug 7.
Palladium-catalyzed C-H diarylation of ferrocenes is described. In the presence of 10 mol % Pd(OAc), direct C-H diarylation reactions of commercially available ferrocenecarboxylic acid with aryl iodides proceeded smoothly to afford diarylated ferrocenes bearing a variety of functional groups in moderate to good yields. The carboxylic group could also act as a remote directing group to result in the third arylation on the other Cp ring of ferrocene.
本文描述了钯催化的二芳基化反应。在 10 mol % Pd(OAc)的存在下，商业可得的二茂铁羧酸与芳基碘化物的直接 C-H 二芳基化反应顺利进行，以中等至良好的收率得到了带有各种官能团的二芳基化二茂铁。羧酸基团也可以作为远程导向基团，导致在二茂铁的另一个 Cp 环上进行第三次芳基化。
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