Gao Kun, Zhu Wenxiu, Liu Weidong, Ma Dujun, Li Heng, Yu Weiji, Wang Lixin, Cao Yafei, Jiang Yong
Guangdong Provincial Key Laboratory of Proteomics, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China.
J Int Med Res. 2019 Sep;47(9):4413-4421. doi: 10.1177/0300060519860686. Epub 2019 Jul 25.
Knee osteoarthritis (KOA) is a chronic inflammatory disease. The monocyte–lymphocyte ratio (MLR) was reported to be a non-invasive, cost-effective marker in various systemic diseases, but it has not yet been investigated in KOA. This cross-sectional study evaluated the diagnostic value of MLR in KOA.
Two hundred and five KOA patients and 120 healthy control subjects were enrolled. Patient data, including age, sex, blood cell counts, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels, red blood cell distribution width, and the Kellgren–Lawrence (KL) score were recorded.
One hundred nineteen patients (55 men, 64 women) were included, with a mean age of 55.47 ± 9.23 years. KOA patients showed a significantly higher MLR, neutrophil–lymphocyte ratio (NLR), and platelet–lymphocyte ratio (PLR) than controls. The MLR area under the curve was 0.81, which was higher than that of NLR and PLR. Multiple logistic regression analysis revealed blood MLR as an independent predictor of KOA. Correlation analysis showed that MLR was positively correlated with ESR and CRP levels. MLR and NLR were significantly higher in KL4 patients than in KL1–3 patients.
MLR has a high diagnostic value for KOA, so could be a reliable disease marker.
膝关节骨关节炎（KOA）是一种慢性炎症性疾病。单核细胞与淋巴细胞比值（MLR）据报道在各种全身性疾病中是一种非侵入性、性价比高的标志物，但尚未在KOA中进行研究。这项横断面研究评估了MLR在KOA中的诊断价值。
纳入205例KOA患者和120例健康对照者。记录患者数据，包括年龄、性别、血细胞计数、红细胞沉降率（ESR）、C反应蛋白（CRP）水平、红细胞分布宽度以及凯尔格伦-劳伦斯（KL）评分。
纳入119例患者（55例男性，64例女性），平均年龄为55.47±9.23岁。KOA患者的MLR、中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）显著高于对照组。曲线下面积MLR为0.81，高于NLR和PLR。多因素逻辑回归分析显示血液MLR是KOA的独立预测因子。相关性分析表明MLR与ESR和CRP水平呈正相关。KL4患者的MLR和NLR显著高于KL1-3患者。
MLR对KOA具有较高的诊断价值，因此可能是一种可靠的疾病标志物。
