一种用于评估光热疗法影响的自噬水平的双模纳米探针。
A dual-mode nanoprobe for evaluation of the autophagy level affected by photothermal therapy.
机构信息
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Dongchuan Road 500, Shanghai 200241, P. R. China.
出版信息
Chem Commun (Camb). 2019 Aug 21;55(65):9673-9676. doi: 10.1039/c9cc03319j. Epub 2019 Jul 25.
A novel dual-mode nanoprobe (Apt@MNPS) was created for the detection of autophagy-related miRNAs to monitor the autophagic level and study the effect of PTT on autophagy. Interestingly, using our developed probe, PTT was found to be able to activate the autophagy by down regulation of miR-18a* and miR-4802, which in turn restricted the PTT efficiency for cancer.
一种新型的双模式纳米探针（Apt@MNPS）被设计用于检测自噬相关 miRNAs，以监测自噬水平并研究 PTT 对自噬的影响。有趣的是，使用我们开发的探针，发现 PTT 能够通过下调 miR-18a* 和 miR-4802 来激活自噬，从而限制 PTT 对癌症的效率。
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