Aho P, Männistö P T
Research Centre, Orion Pharmaceutica, Espoo, Finland.
J Antimicrob Chemother. 1988 Jun;21 Suppl D:29-32. doi: 10.1093/jac/21.suppl_d.29.
The effect of erythromycin, doxycycline and phenoxymethylpenicillin on human polymorphonuclear leucocyte (PMNL) chemotaxis was studied in vitro with Boyden's filter technique. Both erythromycin base and 2'-acetyl erythromycin stearate increased the PMNL chemotaxis significantly at concentrations greater than or equal to 50 microM, 2'-acetyl erythromycin stearate also at concentrations of 2.5-5 microM. Phenoxymethyl-penicillin reduced migration at 500 microM but lower concentrations had no significant effect. Doxycycline prevented migration significantly at concentrations greater than or equal to 50 microM.
采用博伊登滤膜技术在体外研究了红霉素、强力霉素和苯氧甲基青霉素对人多形核白细胞（PMNL）趋化性的影响。红霉素碱和2'-乙酰硬脂酸红霉素在浓度大于或等于50微摩尔时均显著增加PMNL趋化性，2'-乙酰硬脂酸红霉素在2.5 - 5微摩尔浓度时也有此作用。苯氧甲基青霉素在500微摩尔时减少迁移，但较低浓度无显著影响。强力霉素在浓度大于或等于50微摩尔时显著阻止迁移。
