Department of Exercise & Sport Science, University of North Carolina at Chapel Hill.
Department of Kinesiology, University of North Carolina at Charlotte.
J Athl Train. 2019 Jul;54(7):801-807. doi: 10.4085/1062-6050-38-18. Epub 2019 Jul 25.
Lateral ankle sprains (LASs) result in short- and long-term adaptations in the sensorimotor system that are thought to contribute to the development of chronic ankle instability and posttraumatic ankle osteoarthritis. Debate continues as to the appropriateness of rapid return to sport after LASs given the prevalence of long-term consequences.
To examine the short- and long-term effects of prolonged rest, as a model of immobilization, on dynamic balance and gait outcomes after a severe LAS in a mouse model.
Controlled laboratory study.
Research laboratory.
INTERVENTION(S): At 7 weeks of age, 18 male mice (CBA/J) had their right anterior talofibular and calcaneofibular ligaments transected. Mice were then randomized to 1 of 3 groups representing when access to a running wheel postsurgery was gained: at 3 days, 1 week, and 2 weeks.
MAIN OUTCOME MEASURE(S): Dynamic balance and spatial gait characteristics were quantified before surgery (baseline) and at 3 days and 1, 2, 4, 6, 12, 18, 24, 30, 36, 42, 48, and 54 weeks postinjury.
Relative to prolonged rest, resting for only 3 days resulted in worse dynamic balance during the later assessment points (42-54 weeks postinjury, < .01). Mice that underwent a prolonged rest period of 2 weeks crossed the balance beam faster than the group that rested for only 3 days when averaged across all time points ( < .012). Spatial gait characteristics did not differ among the groups ( > .05).
Relative to 3 days of rest, prolonged rest (1 and 2 weeks) after a severe LAS in mice positively affected balance. The apparent benefit of prolonged rest was noted on both dynamic-balance outcomes and performance. Stride length was not altered by the duration of rest after a surgically induced severe LAS in mice. Future research is needed to determine if these results translate to a human model.
外踝扭伤（LAS）会导致感觉运动系统出现短期和长期适应，据认为这会导致慢性踝关节不稳定和创伤后踝关节骨关节炎的发展。鉴于 LAS 后长期后果的普遍性，对于 LAS 后是否应尽快重返运动仍存在争议。
在小鼠模型中，研究严重 LAS 后长时间休息（模拟固定）对动态平衡和步态结果的短期和长期影响。
对照实验室研究。
研究实验室。
在 7 周龄时，18 只雄性 CBA/J 小鼠切断了前距腓韧带和跟腓韧带。然后，将小鼠随机分为 3 组，分别代表手术后获得跑轮使用权的时间：第 3 天、第 1 周和第 2 周。
在手术前（基线）和术后第 3 天以及 1、2、4、6、12、18、24、30、36、42、48 和 54 周时，定量评估动态平衡和空间步态特征。
与长时间休息相比，仅休息 3 天在后期评估点（受伤后 42-54 周，<0.01）时的动态平衡更差。在所有时间点上，与仅休息 3 天的组相比，进行 2 周长时间休息的小鼠更快地穿过平衡梁（<0.012）。各组之间的空间步态特征没有差异（>0.05）。
与休息 3 天相比，小鼠严重 LAS 后长时间休息（1 周和 2 周）对平衡有积极影响。在动态平衡结果和表现上都明显受益于长时间休息。在小鼠手术诱导的严重 LAS 后，休息时间的长短并未改变步幅长度。需要进一步的研究来确定这些结果是否适用于人类模型。
