胚系BRCA2突变与儿童或青少年非霍奇金淋巴瘤风险的关联
Association of Germline BRCA2 Mutations With the Risk of Pediatric or Adolescent Non-Hodgkin Lymphoma.
作者信息
Wang Zhaoming, Wilson Carmen L, Armstrong Gregory T, Hudson Melissa M, Zhang Jinghui, Nichols Kim E, Robison Leslie L
机构信息
Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, Tennessee.
Department of Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee.
出版信息
JAMA Oncol. 2019 Sep 1;5(9):1362-1364. doi: 10.1001/jamaoncol.2019.2203.
Abstract
This study uses whole-genome sequencing to examine whether survivors of childhood lymphoma who are carriers of gene mutation have a greater likelihood of developing adult-onset cancers.
摘要
本研究采用全基因组测序来检验携带基因突变的儿童淋巴瘤幸存者是否更有可能患成年期癌症。
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