[甲型血友病患者的肝移植。1例报告]

[Liver transplantation in hemophilia A. Report of one case].

作者信息

Benítez Carlos, Zúñiga Pamela, Kramer Felipe, Valladares Ximena, Rojas Patricio, Pimentel Eduardo, Gómez Fernando, Cancino Alejandra, Briceño Eduardo, Guerra Juan Francisco, Martínez Jorge

机构信息

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Departamento de Hematología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

出版信息

Rev Med Chil. 2019 Mar;147(3):378-383. doi: 10.4067/S0034-98872019000300378.

DOI:10.4067/S0034-98872019000300378

PMID:31344177

Abstract

Due to blood derivative requirements, many patients with hemophilia were exposed to Hepatitis C virus infection (HCV) before the availability of HCV testing. We report a 46-year-old male with Hemophilia A with a hepatitis virus C infection since 2004 causing a cirrhosis. Due to a hepatopulmonary syndrome, he received a liver allograph using a factor VIII replacement protocol, after eradicating the virus C. He had a good postoperative evolution, and no more factor VIII was required after transplantation until his last assessment.

摘要

由于对血液衍生物的需求，许多血友病患者在丙肝病毒检测可用之前就接触到了丙型肝炎病毒感染（HCV）。我们报告一例46岁的甲型血友病男性患者，自2004年起感染丙型肝炎病毒，导致肝硬化。由于肝肺综合征，在根除丙型肝炎病毒后，他采用了因子VIII替代方案接受了肝脏移植。术后恢复良好，移植后直至最后一次评估都不再需要因子VIII。