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Long-term sequential deferiprone and deferasirox therapy in transfusion-dependent thalassaemia patients: a prospective clinical trial.

作者信息

Vitrano Angela, Ruffo Giovan Battista, Pepe Alessia, D'Ascola Domenico Giuseppe, Caruso Vincenzo, Filosa Aldo, Masera Nicoletta, Pitrolo Lorella, Rigano Paolo, Cuccia Liana, Giangreco Antonino, Di Maggio Rosario, Maggio Aurelio

机构信息

Campus of Haematology Franco and Piera Cutino, AOOR Villa Sofia-V. Cervello, Palermo, Italy.

U.O.C. 7a Pediatria per le Emopatie Ereditarie, Centro di Prevenzione Diagnosi e Cura della Talassemia, A.O. ''G. Di Cristina'', Palermo, Italy.

出版信息

Br J Haematol. 2019 Sep;186(6):e209-e211. doi: 10.1111/bjh.16101. Epub 2019 Jul 25.

DOI:10.1111/bjh.16101
PMID:31344255
Abstract
摘要

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Long-term sequential deferiprone and deferasirox therapy in transfusion-dependent thalassaemia patients: a prospective clinical trial.长期序贯使用去铁酮和地拉罗司治疗依赖输血的地中海贫血患者：一项前瞻性临床试验。
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Daily alternating deferasirox and deferiprone therapy successfully controls iron accumulation in untreatable transfusion-dependent thalassemia patients.每日交替使用地拉罗司和去铁酮疗法成功控制了无法治疗的输血依赖型地中海贫血患者的铁蓄积。
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Optimising management of deferasirox therapy for patients with transfusion-dependent thalassaemia and lower-risk myelodysplastic syndromes.优化依赖输血的地中海贫血和低危骨髓增生异常综合征患者的地拉罗司治疗管理。
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MRI multicentre prospective survey in thalassaemia major patients treated with deferasirox versus deferiprone and desferrioxamine.MRI 多中心前瞻性研究：地拉罗司治疗重型地中海贫血患者与去铁酮和去铁胺的对比。
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引用本文的文献

1
Iron Chelation Therapy.铁螯合疗法
Adv Exp Med Biol. 2025;1480:361-370. doi: 10.1007/978-3-031-92033-2_23.
2
Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia.改善镰状细胞病或地中海贫血患者铁螯合治疗依从性的干预措施。
Cochrane Database Syst Rev. 2023 Mar 6;3(3):CD012349. doi: 10.1002/14651858.CD012349.pub3.
3
An evaluation of deferiprone as twice-a-day tablets or in combination therapy for the treatment of transfusional iron overload in thalassemia syndromes.
评价地拉罗司（ deferiprone ）每日两次服用片剂或联合治疗用于治疗地中海贫血综合征的输血铁过载。
Expert Rev Hematol. 2023 Feb;16(2):81-94. doi: 10.1080/17474086.2023.2178409. Epub 2023 Feb 15.