Manotas M, Sarmiento K, Ibañez-Morantes A, Suárez-Obando F, Gelvez N, López G, Ayala-Ramírez P, Angel J, Prieto J, Tamayo N, Puentes S, Rodríguez C, Tamayo M L, Zarante I
Instituto de Genética Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Carrera 7 No. 40 - 62 Edificio 32, Bogotá, 110231, Colombia.
Departamento de Ciencias Fisiológicas, Facultad de Medicina, Pontificia Universidad Javeriana, Carrera 7 No. 40 - 62 Edificio 31, Barrientos. Bogotá, 110231, Colombia.
Int J Pediatr Otorhinolaryngol. 2019 Nov;126:109594. doi: 10.1016/j.ijporl.2019.109594. Epub 2019 Jul 19.
Congenital defects affecting the auditory and visual capacity of newborns represent a public health problem as they result in substantial disability, directly impacting the quality of life of newborns and their families.
To evaluate risk factors associated with congenital defects that alter hearing or vision in newborns in the city of Bogotá between 2002 and 2016.
Data from the Bogotá Birth Defects Surveillance and Follow-up Program was used, which consolidated data regarding 167 ECLAMC study (Estudio Colaborativo Latino Americano de Malformaciones Congénitas, in spanish) variables in a case-control design to identify risk factors for birth defects after parents provided signed informed consent. Cases were defined as any newborn (alive or stillborn) with a weight greater than 500 g with any visual or hearing abnormality. Controls were defined as newborn in the same hospital and month with no birth defects. Groups were formed according to the case presentation as follows: isolated eye anomaly, isolated ear anomaly, polymalformative, syndromic, and teratogenic.
In total, 402,657 births were reviewed, of which 968 cases had some congenital defects that alter hearing or vision. An association was found between the presence of defects and prematurity, as well as between syndromic cases and increasing maternal age. When comparing cases and controls with the risk of having a birth defect, multiparity had an odds ratio (OR) of 1.47 (95% CI: 1.27-1.71), acute respiratory infection had an OR of 2.41 (95% CI: 1.04-5.58), low maternal education level had an OR of 1.34 (95% CI:1.10-1.62), low paternal education had an OR of 1.42, (95% CI:1.17-1.73), manual labor in the maternal occupation had an OR of 1.31 (95% CI:1.03-1.67), and a history of congenital anomalies in the family had an OR of 1.55 (95% CI:1.19-2.00).
This research allowed the identification of epidemiological data and significant risk factors for congenital defects that alter hearing or vision in the population of Bogotá.
影响新生儿听觉和视觉能力的先天性缺陷是一个公共卫生问题，因为它们会导致严重残疾，直接影响新生儿及其家庭的生活质量。
评估2002年至2016年期间波哥大市与改变新生儿听力或视力的先天性缺陷相关的风险因素。
使用了波哥大出生缺陷监测与随访项目的数据，该项目在病例对照设计中整合了167个拉丁美洲先天性畸形协作研究（西班牙语为Estudio Colaborativo Latino Americano de Malformaciones Congénitas）变量的数据，以便在父母签署知情同意书后识别出生缺陷的风险因素。病例定义为任何体重超过500克且有任何视觉或听力异常的新生儿（活产或死产）。对照定义为同一医院同月出生且无出生缺陷的新生儿。根据病例表现将组分为以下几类：孤立性眼部异常、孤立性耳部异常、多发畸形、综合征性和致畸性。
共审查了402,657例出生病例，其中968例有一些改变听力或视力的先天性缺陷。发现缺陷的存在与早产之间存在关联，综合征性病例与母亲年龄增加之间也存在关联。在比较病例和对照出现出生缺陷的风险时，多产的优势比（OR）为1.47（95%置信区间：1.27 - 1.71），急性呼吸道感染的OR为2.41（95%置信区间：1.04 - 5.58），母亲教育水平低的OR为1.34（95%置信区间：1.10 - 1.62），父亲教育水平低的OR为1.42（95%置信区间：1.
