Salazar-Reviakina Alexander, Sierra-Bretón Manuela, Rumbo Jose, Madariaga Ithzayana, Tovar Catherin, Uribe Mateo, Sequera Carolina, Rodríguez Catherin, Holguín Jorge, Sarmiento Karen, Hurtado-Villa Paula, Zarante Ignacio
27964Pontificia Universidad Javeriana, Bogotá, Colombia.
Institute of Human Genetics, 27964Pontificia Universidad Javeriana, Bogotá, Colombia.
J Child Neurol. 2021 Jun;36(7):509-516. doi: 10.1177/0883073820981514. Epub 2021 Jan 4.
Worldwide prevalence of neural tube defects is between 1.2 and 124.1 per 10 000 live births. This study analyzes risk factors linked with neural tube defects. The study focused on the Surveillance and Monitoring Programs of Congenital Anomalies databases in Bogota and Cali. Births were monitored between 2001 and 2018. Liveborn or stillborn with neural tube defects were defined as cases, using a case-control ratio of 1:4. Paternal age, folic acid supplementation, birth weight, urban or rural origin, maternal and paternal studies, and socioeconomic levels were analyzed. Across the 215 730 births monitored, 147 cases with a rate of 6.82/10 000 live births were found (6.79-6.85). In isolated cases, lower birth weight had a <.01. Paternal age >45 years showed an odds ratio (OR) of 4.24 (1.54-11.65), socioeconomic status 1 and 2, OR of 2.49 (1.63-3.82), maternal primary schooling or lower OR 2.61 (1.28-5.31), and housing in urban areas OR 2.4 (1.4-4.09).
全球神经管缺陷的患病率为每10000例活产中1.2至124.1例。本研究分析了与神经管缺陷相关的危险因素。该研究聚焦于波哥大和卡利的先天性异常监测与监测项目数据库。在2001年至2018年期间对出生情况进行了监测。患有神经管缺陷的活产或死产被定义为病例，病例对照比例为1:4。分析了父亲年龄、叶酸补充情况、出生体重、城乡出身、父母的研究情况以及社会经济水平。在监测的215730例出生中，发现147例病例，活产患病率为6.82/10000（6.79 - 6.85）。在个别病例中，较低的出生体重有<0.01的情况。父亲年龄>45岁的优势比（OR）为4.24（1.54 - 11.65），社会经济地位为1和2的OR为2.49（1.63 - 3.82），母亲接受小学及以下教育的OR为2.61（1.28 - 5.31），以及居住在城市地区的OR为2.4（1.4 - 4.09）。
