Gannon M C, Nuttall F Q
Section of Endocrinology, Metabolism and Nutrition, V.A. Medical Center, Minneapolis, MN 55417.
J Nutr. 1988 Jul;118(7):888-94. doi: 10.1093/jn/118.7.888.
In fasted rats, casein hydrolysate administration resulted in a marked increase in glycogen synthase I activity, no change in phosphorylase a and a marked decrease in glycogen concentration. This occurred with doses as small as 0.5 g/kg body weight. The major reason for an increase in synthase I appeared to be the reduced glycogen concentration, although insulin may play a role early in the time course. The decrease in glycogen in the absence of a change in phosphorylase a most likely is due to a decrease in an allosteric inhibitor. The nature of this inhibitor is unknown.
在禁食的大鼠中，给予酪蛋白水解物导致糖原合酶I活性显著增加，磷酸化酶a无变化，糖原浓度显著降低。体重低至0.5 g/kg的剂量即可出现这种情况。合酶I增加的主要原因似乎是糖原浓度降低，尽管胰岛素可能在早期阶段起作用。在磷酸化酶a无变化的情况下糖原减少很可能是由于变构抑制剂减少。这种抑制剂的性质尚不清楚。
