硒代蛋氨酸可改善秀丽隐杆线虫中过氧化物引起的氧化应激。
Selenoneine ameliorates peroxide-induced oxidative stress in C. elegans.
机构信息
Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.
Institute of Chemistry, Analytical Chemistry, NAWI Graz, University of Graz, Universitaetsplatz 1, 8010 Graz, Austria.
出版信息
J Trace Elem Med Biol. 2019 Sep;55:78-81. doi: 10.1016/j.jtemb.2019.05.012. Epub 2019 May 31.
SCOPE
Selenoneine (2-selenyl-N, N, N-trimethyl-L-histidine), the selenium (Se) analogue of the ubiquitous thiol compound and putative antioxidant ergothioneine, is the major organic selenium species in several marine fish species. Although its antioxidant efficacy has been proposed, selenoneine has been poorly characterized, preventing conclusions on its possible beneficial health effects.
METHODS AND RESULTS
Treatment of Caenorhabditis elegans (C. elegans) with selenoneine for 18 h attenuated the induction of reactive oxygen and nitrogen species (RONS). However, the effect was not immediate, occurring 48 h post-treatment. Total Se and Se speciation analysis revealed that selenoneine was efficiently taken up and present in its original form directly after treatment, with no metabolic transformations observed. 48 h post-treatment, total Se in worms was slightly higher compared to controls and no selenoneine could be detected.
CONCLUSION
The protective effect of selenoneine may not be attributed to the presence of the compound itself, but rather to the activation of molecular mechanisms with consequences at more protracted time points.
范围
硒代氨酸（2-硒基-N，N，N-三甲基-L-组氨酸）是普遍存在的硫醇化合物和假定抗氧化剂麦角硫因的硒类似物，是几种海洋鱼类中主要的有机硒形式。尽管已经提出了其抗氧化功效，但硒代氨酸的特征描述很差，这阻碍了对其可能有益的健康影响的结论。
方法和结果
用硒代氨酸处理秀丽隐杆线虫（C. elegans）18 小时可减弱活性氧和氮物质（RONS）的诱导。然而，这种效果不是即时的，而是在处理后 48 小时发生。总硒和硒形态分析表明，硒代氨酸在处理后立即被有效地吸收并以其原始形式存在，没有观察到代谢转化。处理后 48 小时，与对照组相比，蠕虫中的总硒略高，且无法检测到硒代氨酸。
结论
硒代氨酸的保护作用可能不是归因于该化合物本身的存在，而是归因于激活了具有更持久时间点后果的分子机制。
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