Abdel Rahim I M, Haridi A A, Abdel-Hameed A A
Department of Medicine, University of Gezira, Wad Medani, Sudan.
J Trop Med Hyg. 1988 Jun;91(3):131-7.
Two hundred and ninety-six individuals of whom 126 were children and 170 adults with positive stool for Schistosoma mansoni were randomly given oxamniquine treatment in a dose of either 20, 40 or 60 mg/kg body wt. They were followed in the field for ova excretion at 1, 3 and 6 months for adults and at 1, 3, 6 and 8 months for children. The cure rates in adults at 6 months are 93%, 87% and 73% for the 60, 40, 20 mg/kg-1 treatments in order. For children the cure rates at 6 months are 36%, 58% and 63% and at 8 months are 16%, 21% and 26% for corresponding doses. There is no difference in egg reduction for those not cured between the three treatments at 6 months. It is concluded that oxamniquine need not be given in the previously recommended 60 mg/kg body wt. A choice between 40 and 20 mg/kg body wt is suggested with the 40 mg/kg body wt to be reserved for individuals leaving the endemic area, and the 20 mg/kg body wt for those continuing to stay there with substantial exposure for reinfection. The overall proper cure rates for children with a possible advantage of the low treatment in the long term for this age group is noted.
296名曼氏血吸虫粪便检测呈阳性的个体，其中126名儿童，170名成人，被随机给予20、40或60毫克/千克体重剂量的奥沙尼喹进行治疗。对成人在1、3和6个月以及对儿童在1、3、6和8个月进行现场随访，观察虫卵排泄情况。成人6个月时，60毫克/千克体重、40毫克/千克体重、20毫克/千克体重剂量治疗的治愈率依次为93%、87%和73%。儿童6个月时，相应剂量的治愈率分别为36%、58%和63%，8个月时分别为16%、21%和26%。6个月时，三种治疗方法对未治愈者的虫卵减少情况没有差异。得出结论，奥沙尼喹不必按先前推荐的60毫克/千克体重给药。建议在40毫克/千克体重和20毫克/千克体重之间进行选择，40毫克/千克体重用于即将离开疫区的个体，20毫克/千克体重用于继续留在疫区且有大量再次感染风险的个体。注意到儿童的总体恰当治愈率，该低剂量治疗可能对该年龄组有长期优势。
