Zou Qi, Li Na, Liu Juyuan, Li Xiaolin, Wang Zhuofei, Ai Xiaoman, Tao Fengrong, Qu Mei, Cai Meng, Hu Yunjian
Hospital Infection Prevention and Control Department, Beijing Hospital, National Center of Gerontology, Beijing, China.
Clinical Laboratory Department, Beijing Hospital, National Center of Gerontology, Beijing, China.
Am J Infect Control. 2020 Feb;48(2):199-203. doi: 10.1016/j.ajic.2019.06.011. Epub 2019 Jul 23.
Contamination of drugs used in minimally invasive treatment may to lead to infection outbreaks and catastrophic public health events that require prompt detection and control. Our aim was to investigate the outbreak of Burkholderia cepacia infection and its source in a tertiary care, general hospital in Beijing, China.
We investigated the outbreak of B cepacia infection from January 2017 to March 2018. The investigation included a detailed review of all cases, and field investigations. Environmental and product cultures were performed at the microbiology laboratory in the hospital. Isolates were evaluated for molecular relatedness using pulsed-field gel electrophoresis performed in an independent laboratory.
In total, 9 patients were infected from November 2017 to March 2018, and all patients had undergone the following surgeries: transurethral resection of the prostate (n = 4), perineal prostate biopsy (n = 2), transurethral resection of bladder tumors (n = 2), and ureteroscopy (n = 1). B cepacia was isolated from the urine of 9 patients, blood of 2 patients, grilles used for puncturing, and 2 samples in 1 batch of analgesic gels. Pulsed-field gel electrophoresis confirmed that the isolates from the patients and gels were homologous.
Our investigation revealed that the outbreak of B cepacia infection was caused by drug contamination.
微创治疗中使用的药物污染可能导致感染暴发以及需要迅速检测和控制的灾难性公共卫生事件。我们的目的是调查中国北京一家三级综合医院洋葱伯克霍尔德菌感染的暴发情况及其源头。
我们调查了2017年1月至2018年3月期间洋葱伯克霍尔德菌感染的暴发情况。调查包括对所有病例进行详细回顾以及现场调查。在医院的微生物实验室进行了环境和产品培养。在一个独立实验室使用脉冲场凝胶电泳对分离株进行分子相关性评估。
2017年11月至2018年3月期间，共有9名患者受到感染，所有患者均接受了以下手术：经尿道前列腺切除术（4例）、会阴前列腺活检（2例）、经尿道膀胱肿瘤切除术（2例）和输尿管镜检查（1例）。从9名患者的尿液、2名患者的血液、穿刺用格栅以及一批镇痛凝胶中的2份样品中分离出了洋葱伯克霍尔德菌。脉冲场凝胶电泳证实患者和凝胶中的分离株具有同源性。
我们的调查显示，洋葱伯克霍尔德菌感染的暴发是由药物污染引起的。
