Babichev V N, Bukiia N G, Adamskaia E I
Probl Endokrinol (Mosk). 1988 Mar-Apr;34(2):51-5.
The effect of pharmacological agents (alpha-adrenoblockers alpha-adrenergic stimulators) and dopamine (DA) on LH secretion as well as the effect of local administration of noradrenaline (NA) and DA into the preoptic area (PA) or arcuate nuclei (ARC) on the LH-RH content in hypothalamic nuclei and blood LH and FSH concentration were investigated in experiments on male rats. An inhibitory effect of alpha-adrenoblockers on LH secretion was shown. This effect was reversed by the administration of stimulators DA or alpha-adrenoreceptors. Differences in the type of changes in LH-RH concentration and LH and FSH levels in response to NA and DA administration were established: a stimulating NA effect on the secretion of gonadotropins at the PA level was noted whereas a stimulating DA effect was more noticeable at the ARC level. Catecholamine effects were steroid-related. A conclusion was made that the regulation of tonic secretion of gonadotropins was not restricted to the mediobasal hypothalamus only: the anterior hypothalamus was also involved in control.
在雄性大鼠实验中，研究了药理剂（α-肾上腺素能阻滞剂、α-肾上腺素能刺激剂）和多巴胺（DA）对促黄体生成素（LH）分泌的影响，以及向视前区（PA）或弓状核（ARC）局部注射去甲肾上腺素（NA）和DA对下丘脑核中LH-RH含量以及血液中LH和促卵泡生成素（FSH）浓度的影响。结果显示α-肾上腺素能阻滞剂对LH分泌有抑制作用。给予刺激剂DA或α-肾上腺素受体可逆转这种作用。确定了对NA和DA给药反应时LH-RH浓度以及LH和FSH水平变化类型的差异：在PA水平观察到NA对促性腺激素分泌有刺激作用，而在ARC水平DA的刺激作用更明显。儿茶酚胺的作用与类固醇有关。得出的结论是，促性腺激素的紧张性分泌调节不仅限于下丘脑中间基底部：下丘脑前部也参与了调控。
