Department of Urology, Uludag University, Bursa, Turkey.
Department of Biostatistics, Uludag University, Bursa, Turkey.
Int Urol Nephrol. 2019 Nov;51(11):1941-1947. doi: 10.1007/s11255-019-02238-7. Epub 2019 Jul 26.
The present study aims to biochemically analyze the fluid samples containing stone dust taken during the perioperative period to determine the role of fluid in the prediction of stones in patients treated with ureterorenoscopic procedures. Our secondary aim is to investigate the role of both fluid analysis and stone analysis in predicting the results of the metabolic analysis.
Comparative analyses were performed using fluid samples containing stone dust from 93 patients. Biochemical analysis of fluid containing stone dust was conducted; stone fragments were examined at a separate location using X-ray diffractometry(XRD). Metabolic analysis was performed to patients who provided stone-free status 1 month later. The results of chemical analysis were compared with the results of the XRD analysis.
Patients' stone type was determined with high accuracy using biochemical analysis. Differences were noted in ten patients following biochemical analysis and XRD analysis. Biochemical analysis predicted metabolic disorders in more patients than XRD analysis, particularly for those patients with multiple stone compositions. However, no significant differences between the results of biochemical and XRD analysis methods were found (κ = 0.27; p = 0.002). Moreover, biochemical analysis results revealed metabolic disorders in five patients; these findings were missed by XRD analysis.
Biochemical analysis of fluid taken perioperatively during ureterorenoscopic laser lithotripsy to treat urinary system stone disease was found to determine stone composition with high accuracy. Biochemical analysis of fluid samples taken during the perioperative period is, thus, an easy, reliable and cost-effective test to assess stone composition in patients undergoing ureterorenoscopic procedures.
本研究旨在通过对手术期间采集的含有结石粉尘的液体样本进行生化分析，确定液体在预测接受输尿管镜激光碎石术治疗的患者结石方面的作用。我们的次要目的是研究液体分析和结石分析在预测代谢分析结果方面的作用。
对 93 名患者的含有结石粉尘的液体样本进行了对比分析。对含有结石粉尘的液体进行生化分析；在另一个位置使用 X 射线衍射法（XRD）检查结石碎片。对 1 个月后结石无残留的患者进行代谢分析。将化学分析结果与 XRD 分析结果进行比较。
生化分析能准确确定患者的结石类型。生化分析和 XRD 分析在 10 名患者中存在差异。生化分析预测代谢紊乱的患者多于 XRD 分析，尤其是那些结石成分多样的患者。然而，生化分析和 XRD 分析方法的结果之间无显著差异（κ=0.27；p=0.002）。此外，生化分析结果显示 5 名患者存在代谢紊乱，而 XRD 分析则未发现这些结果。
对接受输尿管镜激光碎石术治疗泌尿系统结石病的患者进行手术期间采集的液体进行生化分析，可准确确定结石成分。因此，对手术期间采集的液体样本进行生化分析是一种评估接受输尿管镜手术的患者结石成分的简单、可靠且具有成本效益的方法。
